Bury-Moné Stéphanie, Thibessard Annabelle, Lioy Virginia S, Leblond Pierre
Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), 91198 Gif-sur-Yvette, France.
Université de Lorraine, INRAE, DynAMic, F-54000 Nancy, France.
Trends Genet. 2023 Nov;39(11):873-887. doi: 10.1016/j.tig.2023.07.008. Epub 2023 Sep 6.
Streptomyces are prolific producers of specialized metabolites with applications in medicine and agriculture. Remarkably, these bacteria possess a large linear chromosome that is genetically compartmentalized: core genes are grouped in the central part, while the ends are populated by poorly conserved genes including antibiotic biosynthetic gene clusters. The genome is highly unstable and exhibits distinct evolutionary rates along the chromosome. Recent chromosome conformation capture (3C) and comparative genomics studies have shed new light on the interplay between genome dynamics in space and time. Here, we review insights that illustrate how the balance between chance (random genome variations) and necessity (structural and functional constraints) may have led to the emergence of spatial structuring of the Streptomyces chromosome.
链霉菌是特殊代谢产物的多产生产者，其产物在医学和农业领域有应用。值得注意的是，这些细菌拥有一条大型线性染色体，该染色体在遗传上是分区的：核心基因聚集在中部，而末端则分布着保守性较差的基因，包括抗生素生物合成基因簇。基因组高度不稳定，并且沿染色体呈现出不同的进化速率。最近的染色体构象捕获（3C）和比较基因组学研究为空间和时间上的基因组动态之间的相互作用提供了新的线索。在这里，我们回顾了一些见解，这些见解阐明了偶然性（随机基因组变异）和必要性（结构和功能限制）之间的平衡可能是如何导致链霉菌染色体空间结构的出现的。
