血清β人绒毛膜促性腺激素水平在异位妊娠中的预测价值：一项横断面研究。
Predictive value of serum βHCG level in ectopic pregnancy: A cross sectional study.
作者信息
Ghanaie Mandana Mansour, Hoshyarmanesh Sanaz, Asgari Seyedeh Maryam, Galebin Seyed Mohammad Asgari, Fakor Fereshteh
机构信息
Department of Obstetrics & Gynecology, Reproductive Health Research Center, Alzahra Hospital, School of Medicine Guilan University of Medical Sciences Rasht Iran.
Guilan University of Medical Sciences Rasht Iran.
出版信息
Health Sci Rep. 2023 Sep 5;6(9):e1442. doi: 10.1002/hsr2.1442. eCollection 2023 Sep.
BACKGROUND AND AIMS
Ectopic pregnancy (EP) is a potentially life-threatening emergency. We investigate the predictive value of serum βHCG level and it's changes from the baseline to the 4th and 7th days after single dose (SD) methotrexate (MTX) treatment in successful treatment of tubal EP. It is important for early diagnosis of EP.
METHODS
In this cross-sectional study, 690 women with tubal EP and under treatment with SD MTX were evaluated. Successful and failed groups were analyzed on the baseline, 4th and 7th days of MTX treatment. Data were analyzed using SPSS22 software. All values of less than 0/05 were considered satistically significant.
RESULTS
SD MTX treatment was successful in 584 (84.7%) patients. The mean baseline ßHCG value was 882.35 ± 430.76 in the successful group and 1083.99 ± 1080.25 in the failed group. There was a 19.53% decrease in ßHCG values between the baseline and 4th days in the successful group and a 12.94% increase in the failed group ( < 0.001). On days baseline, 4 and 7; receiver operating characteristic curve analysis's value was 504.5, 429, 279 for cut off; 58%, 73%, 81% for sensitivity and 51%, 52%, 55% for specificity, respectively.
CONCLUSION
A decrease in the ßHCG value and/or a cut-off decrease of 59.9% on the baseline, 4th day and 81.6% between the baseline and 7th days, can predict the successful treatment of tubal EP with SD MTX.
背景与目的
异位妊娠（EP）是一种可能危及生命的急症。我们研究了单剂量（SD）甲氨蝶呤（MTX）治疗后第4天和第7天血清βHCG水平及其相对于基线水平的变化对输卵管异位妊娠成功治疗的预测价值。这对异位妊娠的早期诊断很重要。
方法
在这项横断面研究中，对690例接受SD MTX治疗的输卵管异位妊娠女性进行了评估。在MTX治疗的基线、第4天和第7天对成功组和失败组进行分析。使用SPSS22软件进行数据分析。所有P值小于0.05被认为具有统计学意义。
结果
584例（84.7%）患者接受SD MTX治疗成功。成功组的平均基线βHCG值为882.35±430.76，失败组为1083.99±1080.25。成功组基线至第4天βHCG值下降19.53%，失败组上升12.94%（P<0.001）。在基线、第4天和第7天，受试者工作特征曲线分析的截断值分别为504.5、429、279；敏感度分别为58%、73%、81%，特异度分别为51%、52%、55%。
结论
βHCG值下降和/或基线时下降59.9%、第4天时下降以及基线至第7天时下降81.6%，可预测SD MTX治疗输卵管异位妊娠成功。
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