He Jia-Li, Xu Hui-Qiong, Yang Jing, Hou Dong-Jiang, Gong Xiao-Yan, Lu Xian-Ying, Wang Wei, Cai Ming-Jin, Yu Yu-Feng, Gao Jing
School of Nursing, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Division of Abdominal Tumor Multimodality Treatment, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Front Psychol. 2023 Aug 23;14:1222798. doi: 10.3389/fpsyg.2023.1222798. eCollection 2023.
Fear of disease progression (FoP) is among the most prevalent and major psychological burdens breast cancer patients encounter. Excessive FoP may result in serious adverse effects for patients. FoP in breast cancer patients has gained attention recently; however, its prevalence in China is unknown.
This meta-analysis and systematic review aimed to assess the overall FoP among Chinese breast cancer patients to make recommendations for treatment and care.
Systematic search databases included PubMed, EMbase, The Cohrane Library, Web of Science, CINAHL, PsycINFO and 4 Chinese databases (Wan Fang Data, CBM, VIP and CNKI). The retrieval time ranged from the database's establishment to March 20, 2023. After two researchers independently evaluated the literature, retrieved information, and assessed the risk of bias for the included literature, Stata 15.1 software was used to conduct a meta-analysis.
A total of 37 moderate or high-quality studies involving 9,689 breast cancer patients were included. Meta-analysis showed that the pooled mean score of FoP for Chinese breast cancer patients was 33.84 [95% (31.91, 35.77)], prediction interval (21.57 ~ 46.11). The subgroup study found that FoP levels varied among breast cancer patients of different regions, ages, educational levels, marital statuses, residences, illness stages, and disease statuses.
Breast cancer patients have higher FoP scores. Healthcare workers should be concerned. We expect that more relevant research will be undertaken and more effective interventions will be developed. Patients can manage their illness and improve their quality of life by reducing their fears.
https://www.crd.york.ac.uk/prospero/, identifier: PROSPERO CRD42023408914.
对疾病进展的恐惧（FoP）是乳腺癌患者面临的最普遍且主要的心理负担之一。过度的FoP可能给患者带来严重的不良影响。乳腺癌患者的FoP问题近来受到关注；然而，其在中国的患病率尚不清楚。
本荟萃分析和系统评价旨在评估中国乳腺癌患者的总体FoP情况，为治疗和护理提供建议。
系统检索的数据库包括PubMed、EMbase、Cochrane图书馆、Web of Science、CINAHL、PsycINFO以及4个中文数据库（万方数据、中国生物医学文献数据库、维普资讯和中国知网）。检索时间从各数据库建库至2023年3月20日。两名研究人员独立评估文献、提取信息并评估纳入文献的偏倚风险后，使用Stata 15.1软件进行荟萃分析。
共纳入37项中度或高质量研究，涉及9689例乳腺癌患者。荟萃分析显示，中国乳腺癌患者FoP的合并平均得分为33.84 [95%可信区间（31.91，35.77）]，预测区间为（21.57～46.11）。亚组研究发现，不同地区、年龄、教育水平、婚姻状况、居住地、疾病分期和疾病状态的乳腺癌患者的FoP水平存在差异。
乳腺癌患者的FoP得分较高。医护人员应予以关注。我们期待开展更多相关研究并开发更有效的干预措施。患者可通过减轻恐惧来更好地应对疾病并提高生活质量。
https://www.crd.york.ac.uk/prospero/，标识符：PROSPERO CRD42023408914。
