Dhaliwal Gurnoor, Batra Jaskaran, Ankireddypalli Anvitha R, Gorle Swathi, Kanugula Ashok Kumar, Kaur Jasleen
Endocrinology, HealthPartners, Minneapolis, USA.
Internal Medicine, University of Pittsburgh Medical Center (UPMC), McKeesport, USA.
Cureus. 2023 Sep 6;15(9):e44776. doi: 10.7759/cureus.44776. eCollection 2023 Sep.
Progesterone hypersensitivity (PH) is a rare hypersensitivity reaction to either endogenous or exogenous progesterone. There are around 200 reported cases of progesterone hypersensitivity in the medical literature. We present the case of a 31-year-old female who presented with cyclical urticaria and angioedema after exogenous progesterone exposure. Her symptoms would begin a few days before her menstrual cycle began and resolve after menstruation. She only had partial recovery of her symptoms with antihistamines, steroids, montelukast, and omalizumab. She needed treatment with oral contraceptives and had a resolution of symptoms, but subsequently developed a recurrence again. Given the rarity of this condition, the diagnosis is often delayed. This diagnosis should be considered for women of reproductive age who present with cyclic hypersensitivity or allergic symptoms.
孕酮超敏反应（PH）是一种对内源性或外源性孕酮的罕见超敏反应。医学文献中报道的孕酮超敏反应病例约有200例。我们报告了一例31岁女性的病例，该女性在接触外源性孕酮后出现周期性荨麻疹和血管性水肿。她的症状会在月经周期开始前几天出现，并在月经后消退。使用抗组胺药、类固醇、孟鲁司特和奥马珠单抗后，她的症状仅部分缓解。她需要口服避孕药进行治疗，症状得到缓解，但随后又复发了。鉴于这种情况罕见，诊断往往会延迟。对于出现周期性超敏反应或过敏症状的育龄女性，应考虑这一诊断。
