Peng Xing Yue Larry, Peng Linghan, Guo Yaxin
Biology Department, Xiamen University, Xiamen 361102, Fujian, China.
iScience. 2023 Aug 17;26(9):107659. doi: 10.1016/j.isci.2023.107659. eCollection 2023 Sep 15.
Actively controlled nanoliter fluid circuits are an urgently needed technology in electronics, biomedicine, chemical synthesis, and biosensing. The difficulty lies in how to drive the microfluid in an isolated and airtight manner in glass wafer. We used a magnetic oscillator pump to realize the switching of the circulation direction and controlling the flow rate of the 10nL fluid. Results of two-dimensional numerical simulations shows that the flow field can reach a steady state and a stable flow can be obtained. The contribution of each vibration cycle to the flow rate is proportional to the frequency, decays exponentially with the viscosity, is proportional to the 4.2 power of the amplitude, and is proportional to the radius. Compared with the existing fluid technology, this technology realizes the steering and flow control of a fully enclosed magnetic control fluid circuit as small as 10nL in hard materials for the first time.
主动控制的纳升流体回路是电子学、生物医学、化学合成和生物传感领域急需的技术。难点在于如何在玻璃晶圆中以隔离且气密的方式驱动微流体。我们使用磁振荡器泵实现了循环方向的切换并控制10nL流体的流速。二维数值模拟结果表明流场可以达到稳态并获得稳定的流动。每个振动周期对流速的贡献与频率成正比，随粘度呈指数衰减，与振幅的4.2次幂成正比，与半径成正比。与现有流体技术相比，该技术首次在硬质材料中实现了对小至10nL的全封闭磁控流体回路的转向和流量控制。
