Li Nan, Gu Xufang, Liu Fanqi, Zhang Yao, Sun Yanjun, Gao Shengwei, Wang Baohe, Zhang Chen
Tianjin University of Chinese Medicine, Tianjin, China.
The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Front Pharmacol. 2023 Aug 23;14:1202718. doi: 10.3389/fphar.2023.1202718. eCollection 2023.
In this review, we investigated the potential mechanism of Total Salvianolic Acid Injection (TSI) in protecting against myocardial ischemia reperfusion injury (MI/RI). To achieve this, we predicted the component targets of TSI using Pharmmapper and identified the disease targets of MI/RI through GeneCards, DisGenNET, and OMIM databases. We constructed protein-protein interaction networks by analyzing the overlapping targets and performed functional enrichment analyses using Gene Ontology and Kyoto Encyclopedia of Genes and Genomes. Our analysis yielded 90 targets, which were implicated in the potential therapeutic effects of TSI on MI/RI. Seven critical signaling pathways significantly contributed to TSI's protective effects, namely, PI3K signaling, JAK-STAT signaling, Calcium signaling, HIF-1 signaling, Nuclear receptor signaling, Cell Cycle, and Apoptosis. Subsequently, we conducted a comprehensive literature review of these seven key signaling pathways to gain further insights into their role in the TSI-mediated treatment of MI/RI. By establishing these connections, our study lays a solid foundation for future research endeavours to elucidate the molecular mechanisms through which TSI exerts its beneficial effects on MI/RI.
在本综述中，我们研究了注射用丹参总酚酸（TSI）预防心肌缺血再灌注损伤（MI/RI）的潜在机制。为此，我们使用Pharmmapper预测TSI的成分靶点，并通过GeneCards、DisGenNET和OMIM数据库确定MI/RI的疾病靶点。我们通过分析重叠靶点构建蛋白质-蛋白质相互作用网络，并使用基因本体论和京都基因与基因组百科全书进行功能富集分析。我们的分析产生了90个靶点，这些靶点与TSI对MI/RI的潜在治疗作用有关。七个关键信号通路对TSI的保护作用有显著贡献，即PI3K信号通路、JAK-STAT信号通路、钙信号通路、HIF-1信号通路、核受体信号通路、细胞周期和细胞凋亡。随后，我们对这七个关键信号通路进行了全面的文献综述，以进一步了解它们在TSI介导的MI/RI治疗中的作用。通过建立这些联系，我们的研究为未来阐明TSI对MI/RI发挥有益作用的分子机制的研究奠定了坚实的基础。
