Brooks A M, Grant G, Gillies W E
Aust N Z J Ophthalmol. 1986 Aug;14(3):189-97. doi: 10.1111/j.1442-9071.1986.tb00035.x.
Fluorescein angiography of the iris vasculature and specular microscopy of the corneal endothelium were used to examine two important anterior chamber tissues in cases of heterochromic cyclitis, classical chronic cyclitis and some cases of iridocyclitis. The 13 cases of heterochromic cyclitis and eight cases of classical chronic cyclitis all showed vascular hypoperfusion of the iris, except for two young females with heterochromia. In these cyclitic eyes there was pupillary leakage of dye and all but one young female with heterochromia showed evidence of microneovascularization of the iris. Most patients showed evidence of abnormalities of the corneal endothelium, but this was most marked in elderly patients with heterochromic cyclitis, probably due to the long duration of the condition. Six of the patients with chronic cyclitis had bilateral disease and five of these were elderly women with glaucoma and grey irides, the group being distinct enough to form a discrete clinical entity. Seventeen of the patients with chronic cyclitis were females with grey irides suggesting that this type of patient is more susceptible to cyclitis. Patients with acute iridocyclitis showed little abnormality on fluorescein angiography, while those with recurrent or chronic disease showed vascular hypoperfusion and microneovascularization suggesting that these changes in the iris contribute to the chronicity of the condition. It is suggested that hypoperfusion and microneovascularization of the iris and abnormal permeability are important factors in the production of chronic cyclitis, and that the integrity of the corneal endothelium is affected by these changes if they operate over a long period of time.
利用虹膜血管荧光血管造影术和角膜内皮镜面显微镜检查法，对异色性睫状体炎、典型慢性睫状体炎以及部分虹膜睫状体炎病例的两个重要前房组织进行了检查。13例异色性睫状体炎和8例典型慢性睫状体炎患者，除2例患有异色症的年轻女性外，均表现出虹膜血管灌注不足。在这些患有睫状体炎的眼中，存在染料的瞳孔渗漏，除1例患有异色症的年轻女性外，其余均显示有虹膜微血管形成的迹象。大多数患者表现出角膜内皮异常的证据，但在患有异色性睫状体炎的老年患者中最为明显，这可能是由于病情持续时间较长所致。6例慢性睫状体炎患者患有双侧疾病，其中5例为患有青光眼且虹膜呈灰色的老年女性，该组患者特征明显，足以构成一个独立的临床实体。17例慢性睫状体炎患者为虹膜呈灰色的女性，这表明这类患者更容易患睫状体炎。急性虹膜睫状体炎患者在荧光血管造影上几乎没有异常表现，而复发或慢性疾病患者则表现出血管灌注不足和微血管形成，提示虹膜的这些变化导致了病情的慢性化。研究表明，虹膜灌注不足、微血管形成以及通透性异常是导致慢性睫状体炎的重要因素，并且如果这些变化长期存在，角膜内皮的完整性会受到影响。
