From the Department of Radiology, Cambridge University Hospitals, Biomedical Campus, Cambridge, CB2 0QQ, England (S.S.D., E.S., F.A.G.); Department of Physiology, Anatomy, and Genetics (C.R., A.S., J.T.G., D.J.T.) and the Oxford Centre for Clinical Magnetic Resonance Research (A.S., J.T.G., D.J.T.), University of Oxford, Oxford, England; Department of Radiology, Oxford University Hospitals, Oxford, England (J.M., J.T.G.); Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, England (J.T.G.); Department of Radiology, University of Cambridge, Cambridge, England (E.S., F.A.G.); Cancer Research UK Cambridge Centre, Cambridge, England (F.A.G.); and Joint Department of Medical Imaging, University Health Network, University of Toronto, Toronto, Canada (E.S.).
Radiol Imaging Cancer. 2023 Sep;5(5):e230005. doi: 10.1148/rycan.230005.
Hyperpolarized carbon 13 MRI (C MRI) is a novel imaging approach that can noninvasively probe tissue metabolism in both normal and pathologic tissues. The process of hyperpolarization increases the signal acquired by several orders of magnitude, allowing injected C-labeled molecules and their downstream metabolites to be imaged in vivo, thus providing real-time information on kinetics. To date, the most important reaction studied with hyperpolarized C MRI is exchange of the hyperpolarized C signal from injected [1-C]pyruvate with the resident tissue lactate pool. Recent preclinical and human studies have shown the role of several biologic factors such as the lactate dehydrogenase enzyme, pyruvate transporter expression, and tissue hypoxia in generating the MRI signal from this reaction. Potential clinical applications of hyperpolarized C MRI in oncology include using metabolism to stratify tumors by grade, selecting therapeutic pathways based on tumor metabolic profiles, and detecting early treatment response through the imaging of shifts in metabolism that precede tumor structural changes. This review summarizes the foundations of hyperpolarized C MRI, presents key findings from human cancer studies, and explores the future clinical directions of the technique in oncology. Hyperpolarized Carbon 13 MRI, Molecular Imaging, Cancer, Tissue Metabolism © RSNA, 2023.
基于 13C 的极化磁共振成像（13C MRI）是一种新颖的成像方法，可无创性地探测正常和病理组织中的组织代谢。极化过程使信号增强了几个数量级，从而可以对注射的 13C 标记分子及其下游代谢产物进行体内成像，从而提供动力学的实时信息。迄今为止，用 13C 极化 MRI 研究的最重要的反应是从注射的[1-13C]丙酮酸与局部组织乳酸池之间的 13C 信号交换。最近的临床前和人体研究表明，乳酸脱氢酶、丙酮酸转运蛋白表达和组织缺氧等多种生物学因素在产生这种反应的 MRI 信号中起作用。基于代谢对肿瘤分级、基于肿瘤代谢谱选择治疗途径以及通过成像检测代谢变化来早期检测治疗反应，是 13C 极化 MRI 在肿瘤学中的潜在临床应用。本综述总结了 13C 极化 MRI 的基础，介绍了人体癌症研究的关键发现，并探讨了该技术在肿瘤学中的未来临床方向。
基于 13C 的极化磁共振成像、分子成像、癌症、组织代谢 © 美国放射学会，2023 年。
