Doctor from Changchun University of Chinese Medicine, Changchun City, Jilin Province, China.
Chief Physician of Jilin Academy of Chinese Medicine, Chaoyang District, Changchun City, Jilin Province, China.
Medicine (Baltimore). 2023 Sep 8;102(36):e35142. doi: 10.1097/MD.0000000000035142.
Ferroptosis is an emerging form of programmed cell death triggered by iron-dependent lipid peroxidation and reactive oxygen species (ROS). Alzheimer disease (AD), a neurodegenerative disorder, is characterized by the degeneration of nerve cells. Recent research has indicated a significant association between ferroptosis and AD; however, the precise underlying mechanism remains elusive. It is postulated that ferroptosis may impact the accumulation of iron ions within the body by influencing iron metabolism, amino acid metabolism, and lipid metabolism, ultimately leading to the induction of ferroptosis in nerve cells. This article centers on the attributes and regulatory mechanism of ferroptosis, the correlation between ferroptosis and AD, and the recent advancements in the therapeutic approach of targeting ferroptosis for the treatment of AD. These results suggest that ferroptosis could potentially serve as a pivotal focus in future research on AD.
铁死亡是一种由铁依赖性脂质过氧化和活性氧（ROS）触发的新兴的程序性细胞死亡形式。阿尔茨海默病（AD）是一种神经退行性疾病，其特征是神经细胞的退化。最近的研究表明，铁死亡与 AD 之间存在显著关联；然而，其确切的潜在机制仍难以捉摸。据推测，铁死亡可能通过影响铁代谢、氨基酸代谢和脂质代谢来影响体内铁离子的积累，最终导致神经细胞发生铁死亡。本文主要关注铁死亡的特征和调控机制、铁死亡与 AD 的相关性，以及针对铁死亡治疗 AD 的治疗方法的最新进展。这些结果表明，铁死亡可能成为未来 AD 研究的一个重要焦点。
