Gianatti Michele, Garvert Anna Christina, Lenkey Nora, Ebbesen Nora Cecilie, Hennestad Eivind, Vervaeke Koen
Institute of Basic Medical Sciences, Section of Physiology, University of Oslo, Oslo, Norway.
Institute of Basic Medical Sciences, Section of Physiology, University of Oslo, Oslo, Norway.
Cell Rep. 2023 Sep 26;42(9):113109. doi: 10.1016/j.celrep.2023.113109. Epub 2023 Sep 7.
Neuronal signals encoding the animal's position widely modulate neocortical processing. While these signals are assumed to depend on hippocampal output, their origin has not been investigated directly. Here, we asked which brain region sends position information to the retrosplenial cortex (RSC), a key circuit for memory and navigation. We comprehensively characterized the long-range inputs to agranular RSC using two-photon axonal imaging in head-fixed mice performing a spatial task in darkness. Surprisingly, most long-range pathways convey position information, but with notable differences. Axons from the secondary motor and posterior parietal cortex transmit the most position information. By contrast, axons from the anterior cingulate and orbitofrontal cortex and thalamus convey substantially less position information. Axons from the primary and secondary visual cortex contribute negligibly. This demonstrates that the hippocampus is not the only source of position information. Instead, the RSC is a hub in a distributed brain network that shares position information.
编码动物位置的神经元信号广泛调节新皮层的处理过程。虽然这些信号被认为依赖于海马体输出，但其起源尚未得到直接研究。在这里，我们探究了哪个脑区向压后皮质（RSC）发送位置信息，RSC是记忆和导航的关键回路。我们使用双光子轴突成像技术，全面表征了在黑暗中执行空间任务的头部固定小鼠的无颗粒RSC的长程输入。令人惊讶的是，大多数长程通路都传递位置信息，但存在显著差异。来自次级运动皮层和顶叶后皮质的轴突传递的位置信息最多。相比之下，来自前扣带回、眶额皮质和丘脑的轴突传递的位置信息要少得多。来自初级和次级视觉皮层的轴突贡献可忽略不计。这表明海马体不是位置信息的唯一来源。相反，RSC是一个共享位置信息的分布式脑网络中的枢纽。
