Department of Anesthesiology, Sichuan Provincial People' Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, China.
PLoS One. 2023 Sep 8;18(9):e0291171. doi: 10.1371/journal.pone.0291171. eCollection 2023.
Excision of intracranial meningioma has been associated with major intraoperative blood loss (IBL). The objective of the study was to identify factors affecting IBL during removal of meningioma.
We retrospectively studied medical records of 530 adult patients who underwent surgery for intracranial meningioma at Sichuan Provincial People's Hospital between September 2018 and May 2022. We obtained the following data from each patient's medical chart: age, sex, height, weight, comorbidities, blood pressure, history of smoking and alcohol, imaging examination findings, pathologic diagnosis, albumin, creatinine, calcium, magnesium, hemoglobin (Hb), hematocrit, platelet count, activated partial thromboplastin time, international normalized ratio, fibrinogen concentration and blood transfusion. Univariate and multivariate analyses were performed to identify risk factors for greater IBL during removal of intracranial meningioma.
A total of 530 patients were included in our study. Univariate analysis revealed that sex (p = 0.004), two-dimensional (2D) tumor area (p < 0.001), sinus involvement (p = 0.014), World Health Organization grade (p = 0.015), preoperative albumin level (p = 0.032), preoperative Hb level (p = 0.001) and preoperative platelet count (p = 0.004) were significantly associated with greater IBL. Multivariate analysis revealed that greater 2D tumor area (p < 0.001), higher preoperative albumin concentration (p = 0.029) and higher preoperative platelet count (p = 0.03) were independent risk factors for greater IBL in resection of intracranial meningioma.
Larger tumor size, higher preoperative albumin concentration and higher preoperative platelet count were identified as independent risk factors for greater IBL in resection of intracranial meningioma.
切除颅内脑膜瘤与术中大量失血（IBL）有关。本研究的目的是确定影响脑膜瘤切除术中 IBL 的因素。
我们回顾性研究了 2018 年 9 月至 2022 年 5 月在四川省人民医院接受颅内脑膜瘤手术的 530 例成年患者的病历。从每位患者的病历中获取以下数据：年龄、性别、身高、体重、合并症、血压、吸烟和饮酒史、影像学检查结果、病理诊断、白蛋白、肌酐、钙、镁、血红蛋白（Hb）、血细胞比容、血小板计数、活化部分凝血活酶时间、国际标准化比值、纤维蛋白原浓度和输血。进行单因素和多因素分析，以确定颅内脑膜瘤切除术中 IBL 增加的危险因素。
本研究共纳入 530 例患者。单因素分析显示，性别（p = 0.004）、二维（2D）肿瘤面积（p < 0.001）、窦受累（p = 0.014）、世界卫生组织分级（p = 0.015）、术前白蛋白水平（p = 0.032）、术前 Hb 水平（p = 0.001）和术前血小板计数（p = 0.004）与 IBL 增加显著相关。多因素分析显示，2D 肿瘤面积较大（p < 0.001）、术前白蛋白浓度较高（p = 0.029）和术前血小板计数较高（p = 0.03）是颅内脑膜瘤切除术中 IBL 增加的独立危险因素。
较大的肿瘤大小、较高的术前白蛋白浓度和较高的术前血小板计数被确定为颅内脑膜瘤切除术中 IBL 增加的独立危险因素。
