Uguz Faruk, Sharma Verinder, Boyce Philip, Clark Crystal T, Galbally Megan, Koukopoulos Alexia, Marsh Wendy, Stevens Anja, Viguera Adele
From the Department of Psychiatry, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.
Schulich School of Medicine and Dentistry, The University of Western Ontario; Lawson Health Research Institute; Parkwood Institute Mental Health, Perinatal Mental Health Clinic, London Health Sciences Center, London, Ontario, Canada.
J Clin Psychopharmacol. 2023;43(5):434-452. doi: 10.1097/JCP.0000000000001740.
Many women with bipolar disorder experience episodes of illness or relapses over the perinatal period, especially in the immediate postpartum period. Risks associated with treated/untreated psychopathologies and fetal exposure to bipolar medications make the management of bipolar disorder during these periods challenging for clinicians and patients. In light of the available effectiveness and reproductive safety data, the current clinical update based on the opinions of a group of international perinatal psychiatry authors recommends general considerations and specific management strategies for each possible clinical scenario, including mixed features, predominant polarity, diagnosis of subtypes of bipolar disorder, severity of previous episodes, and risk of recurrence of mood episodes.
许多双相情感障碍女性在围产期会经历疾病发作或复发,尤其是在产后即刻。与已治疗/未治疗的精神病理状态以及胎儿接触双相情感障碍药物相关的风险,使得在这些时期对双相情感障碍的管理对临床医生和患者而言都具有挑战性。鉴于现有的有效性和生殖安全性数据,基于一组国际围产期精神病学作者的意见编写的当前临床更新内容针对每种可能的临床情况推荐了一般注意事项和具体管理策略,包括混合特征、主要极性、双相情感障碍亚型的诊断、既往发作的严重程度以及情绪发作复发的风险。