围产期双相障碍的疾病进程和治疗进展。
Course of Illness and Treatment Updates for Bipolar Disorder in the Perinatal Period.
机构信息
Department of Psychiatry, University of Colorado School of Medicine - Anschutz Medical Campus, Aurora, CO, USA.
Helen and Arthur E. Johnson Depression Center, University of Colorado School of Medicine - Anschutz Medical Campus, 13199 East Montview Blvd, Suite 330, Aurora, CO, 80045, USA.
出版信息
Curr Psychiatry Rep. 2022 Feb;24(2):111-120. doi: 10.1007/s11920-022-01323-6. Epub 2022 Feb 15.
PURPOSE OF REVIEW
The perinatal period is a time of increased vulnerability for people with bipolar disorder (BD). The purpose of this review is to provide an update of the literature from the last 3 years regarding course of illness and treatments for BD in the perinatal period to guide clinical care.
RECENT FINDINGS
Postpartum manic and depressive episodes are emerging as having a unique presentation that may differentiate them from non-perinatal mood episodes. Many important updates regarding medication treatment in the perinatal period have been published recently that have considered the risks of untreated illness versus treatment risks in this population.' Despite significant research, there are still gaps in knowledge regarding safety and efficacy of medications for the mother and child. Crucial future areas of study include improved screening guidelines, randomized controlled trials examining medication safety in pregnancy and lactation, and efficacy of nonpharmacologic treatments.
目的综述
围产期是双相情感障碍（BD）患者易发病的时期。本文综述的目的是提供过去 3 年中有关围产期 BD 疾病过程和治疗的文献更新，以指导临床护理。
最近的发现
产后躁狂和抑郁发作的表现可能与非围产期情绪发作不同，具有独特的表现。最近发表了许多关于围产期药物治疗的重要更新，这些更新考虑了未治疗疾病的风险与该人群治疗风险。尽管进行了大量研究，但在药物对母亲和儿童的安全性和疗效方面仍存在知识空白。未来重要的研究领域包括改进的筛查指南、在妊娠和哺乳期评估药物安全性的随机对照试验，以及非药物治疗的疗效。
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