Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY.; New York Proton Center, New York, NY..
Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY.; New York Proton Center, New York, NY.
Semin Radiat Oncol. 2023 Oct;33(4):407-415. doi: 10.1016/j.semradonc.2023.06.006.
Advances in proton therapy have garnered much attention and speculation in recent years as the indications for proton therapy have grown beyond pediatric, prostate, spine, and ocular tumors. To achieve and maintain consistent access to this cancer treatment and to ensure the future viability and availability of proton centers in the United States, a call for evidence has been heard and answered by proton radiation oncologists. Answers provided in this review include the evolution of proton therapy research, rationale for proton clinical trial design, challenges in and barriers to the conduct of proton therapy research, and other unique considerations for the study of proton therapy.
近年来，随着质子治疗的适应证不断扩大，超出了儿科、前列腺、脊柱和眼部肿瘤的范畴，质子治疗技术的发展引起了广泛关注和猜测。为了能够持续获得这种癌症治疗方法，并确保质子中心在美国未来的生存能力和可用性，质子放射肿瘤学家已经对这一呼吁进行了研究并给出了答案。本综述中提供的答案包括质子治疗研究的发展、质子临床试验设计的原理、质子治疗研究开展过程中的挑战和障碍，以及质子治疗研究的其他独特考虑因素。
