NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Key Laboratory of Respiratory Disease Pathogenomics, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Nat Commun. 2023 Sep 8;14(1):5537. doi: 10.1038/s41467-023-41264-z.
Bats, recognized as considerable reservoirs for coronaviruses (CoVs), serve as natural hosts for several highly pathogenic CoVs, including SARS-CoV and SARS-CoV-2. Investigating the bat CoV community provides insights into the origin for highly pathogenic CoVs and highlights bat CoVs with potential spillover risks. This study probes the evolution, recombination, host range, geographical distribution, and cross-species transmission characteristics of bat CoVs across China and its associated CoVs in other regions. Through detailed research on 13,064 bat samples from 14 provinces of China, 1141 CoV strains are found across 10 subgenera and one unclassified Alpha-CoV, generating 399 complete genome sequences. Within bat CoVs, 11 new CoV species are identified and 425 recombination events are detected. Bats in southern China, particularly in Yunnan province, exhibit a pronounced diversity of CoVs. Limited sampling and low detection rates exist for CoVs in Myotacovirus, Nyctacovirus, Hibecovirus, Nobecovirus in China. The genus Myotis is highlighted as a potential ancestral host for Alpha-CoV, with the genus Hipposideros suggested as a likely progenitor host for bat-associated Beta-CoV, indicating the complexity of cross-species transmission dynamics. Through the comprehensive analysis, this study enriches the understanding of bat CoVs and offers a valuable resource for future research.
蝙蝠被认为是冠状病毒（CoV）的重要宿主，是几种高致病性 CoV 的天然宿主，包括 SARS-CoV 和 SARS-CoV-2。研究蝙蝠 CoV 群落有助于了解高致病性 CoV 的起源，并突出具有潜在溢出风险的蝙蝠 CoV。本研究探究了中国境内及其他地区相关 CoV 中蝙蝠 CoV 的进化、重组、宿主范围、地理分布和跨种传播特征。通过对来自中国 14 个省的 13064 个蝙蝠样本进行详细研究，发现了 1141 株 CoV 株，分布在 10 个亚属和一个未分类的 Alpha-CoV 中，生成了 399 个完整基因组序列。在蝙蝠 CoV 中，鉴定出 11 种新的 CoV 物种，并检测到 425 个重组事件。中国南方，特别是云南省的蝙蝠 CoV 多样性显著。中国的 Myotacovirus、Nyctacovirus、Hibecovirus 和 Nobecovirus 中 CoV 的采样和检测率有限。Myotis 属被认为是 Alpha-CoV 的潜在原始宿主，Hipposideros 属可能是蝙蝠相关 Beta-CoV 的起源宿主，这表明跨种传播动态的复杂性。通过全面分析，本研究丰富了对蝙蝠 CoV 的认识，并为未来的研究提供了有价值的资源。
