University of Health Sciences Turkey, Haseki Training and Research Hospital, Internal Medicine Clinic, Sultangazi, İstanbul, Turkey.
Kahramanmaraş Necip Fazıl City Hospital, Internal Medicine Clinic, Kahramanmaraş, Turkey.
Ir J Med Sci. 2024 Apr;193(2):733-739. doi: 10.1007/s11845-023-03518-z. Epub 2023 Sep 9.
Hypermagnesemia is one of the vital electrolyte disturbances and is associated with such chronic conditions as cardiovascular, endocrinologic, renal diseases, and malignancy.
This study evaluates the association between hypermagnesemia and clinical course in hospitalized patients.
This study was conducted at the University of Health Sciences Haseki Training and Research Hospital Internal Medicine Clinic. We evaluated a total of 3850 patients. 2130 patients have met the inclusion criteria were included in the study. Those who were discharged with healing were evaluated as having a good prognosis. Patients who died or were transferred to the intensive care unit (ICU) were defined as having a poor prognosis. We divided the patients' serum magnesium levels into four quartiles and examined the clinical course/conditions of the patients.
Of 2130 patients, 1013 (51.9%) were female. The mean age of patients with poor prognoses (69.2 ± 14.9) was higher than those with good prognoses (59.7 ± 19.1). Hypermagnesemia (4th quartile) was detected in 61 (33.9%), and hypomagnesemia (1st quartile) was found in 42 (23.3%) patients out of 180 patients with poor clinical outcomes. It was statistically significant that hypermagnesemia was more common in patients with poor prognoses (p: 0.002). Chronic kidney disease (CKD) was diagnosed in 258 (53.3%) of 484 hypermagnesemia patients. Hypermagnesemia was found to be more common in patients with CKD, which was statistically significant (p: 0.003).
Hypermagnesemia is associated with poor prognosis independent of comorbidities. Besides hypomagnesemia, hypermagnesemia should be considered a critical electrolyte imbalance.
高镁血症是一种重要的电解质紊乱，与心血管、内分泌、肾脏疾病和恶性肿瘤等慢性疾病有关。
本研究评估高镁血症与住院患者临床病程的关系。
本研究在健康科学大学 Haseki 培训和研究医院内科诊所进行。我们评估了总共 3850 名患者。符合纳入标准的 2130 名患者被纳入研究。那些治愈出院的患者被评估为预后良好。死亡或转至重症监护病房（ICU）的患者被定义为预后不良。我们将患者的血清镁水平分为四等分，并检查患者的临床病程/状况。
在 2130 名患者中，有 1013 名（51.9%）为女性。预后不良（69.2±14.9）患者的平均年龄高于预后良好（59.7±19.1）患者。在 180 名临床结局不佳的患者中，有 61 名（33.9%）存在高镁血症（第 4 四分位），42 名（23.3%）存在低镁血症（第 1 四分位）。预后不良患者中高镁血症更为常见，这具有统计学意义（p：0.002）。在 258 名（53.3%）高镁血症患者中诊断出慢性肾脏病（CKD）。高镁血症在 CKD 患者中更为常见，这具有统计学意义（p：0.003）。
高镁血症与合并症无关，与不良预后相关。除了低镁血症外，高镁血症也应被视为一种严重的电解质失衡。
