Gandini Annalice, Bauckneht Matteo, Sofia Luca, Tomasello Laura, Fornarini Giuseppe, Zanardi Elisa
Medical Oncology 1, IRCCS Ospedale Policlinico San Martino, 16132 Genova, Italy.
Department of Internal Medicine and Medical Sciences (DiMI), School of Medicine, University of Genova, 16132 Genova, Italy.
Diagnostics (Basel). 2023 Aug 23;13(17):2733. doi: 10.3390/diagnostics13172733.
Prostate cancer still represents one of the most frequent cancers and causes of death worldwide, despite the huge therapeutic advances in the last decades. The introduction into clinical practice of prostate-specific membrane antigen positron emission tomography/computed tomography (PSMA PET/CT) has significantly improved diagnostic capacity, allowing for the identification of lesions previously undetectable. The case we are presenting is about a 90-year-old man affected by metastatic prostate cancer and treated with hormonal therapies. At the second progression, the restaging with PSMA PET/CT pointed out a millimetric cardiac intra-atrial metastasis, on which little/scarce literature data are still available. On one hand, this finding confirms the high sensitivity of this technique, which should be preferred over traditional imaging. On the other hand, it suggests that introducing next-generation imaging into clinical practice may provide novel insights about prostate cancer metastatic spread.
尽管在过去几十年里治疗取得了巨大进展，但前列腺癌仍是全球最常见的癌症之一和主要死因。前列腺特异性膜抗原正电子发射断层扫描/计算机断层扫描（PSMA PET/CT）引入临床实践后，显著提高了诊断能力，能够识别先前无法检测到的病变。我们介绍的这个病例是关于一名90岁的男性，他患有转移性前列腺癌并接受了激素治疗。在第二次病情进展时，PSMA PET/CT重新分期发现了一个毫米级的心脏心房内转移灶，目前关于该转移灶的文献数据仍然很少。一方面，这一发现证实了该技术的高敏感性，相较于传统成像技术，它更具优势。另一方面，这表明将新一代成像技术引入临床实践可能会为前列腺癌的转移扩散提供新的见解。
