Lazar Alin, Sporea Ioan, Lungeanu Diana, Mare Ruxandra, Lupusoru Raluca, Popescu Alina, Danila Mirela, Deleanu Alexandra, Dan Isabel, Lascau Andrada, Popa Alexandru, Sirli Roxana
Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Center for Advanced Research in Gastroenterology and Hepatology, "Victor Babeș" University of Medicine and Pharmacy, 300041 Timișoara, Romania.
Center for Modeling Biological Systems and Data Analysis, "Victor Babeș" University of Medicine and Pharmacy, 300041 Timișoara, Romania.
Diagnostics (Basel). 2023 Aug 30;13(17):2803. doi: 10.3390/diagnostics13172803.
Vibration-controlled transient elastography (VCTE) was the first non-invasive method used for assessing liver fibrosis in patients with chronic liver disease. Over the years, many studies have evaluated its performance. It is now used globally, and, in some countries, it represents the primary step in evaluating liver fibrosis. The aim of this study is to assess the feasibility of VCTE and highlight the prevalence of liver fibrosis stages assessed by VCTE in a large cohort of patients at a single study center. We also aimed to observe the trends in liver stiffness (LS) values over the years according to each type of hepatopathy. A retrospective study was conducted over a period of 13 years (2007-2019) and included patients who presented to our clinic for LS measurements (LSMs), either with known liver diseases or with suspected liver pathology who were undergoing fibrosis screening. The database contained a total of 23,420 measurements. Valid LSMs were obtained in 90.91% (21,291/23,420) of the cases, while 2129 (9.09%) of the measurements were either failed or unreliable. In untreated patients with chronic viral hepatitis, LS values tended to increase during the years, while in patients undergoing antiviral therapy LS values significantly decreased. Our comprehensive study, one of the largest of its kind spanning 13 years, emphasizes the reliability and significance of VCTE in real-world clinical settings.
振动控制瞬时弹性成像（VCTE）是用于评估慢性肝病患者肝纤维化的首个非侵入性方法。多年来，许多研究评估了其性能。目前它在全球范围内得到应用，在一些国家，它是评估肝纤维化的首要步骤。本研究的目的是评估VCTE的可行性，并突出在单个研究中心的一大群患者中通过VCTE评估的肝纤维化阶段的患病率。我们还旨在观察多年来根据每种肝病类型肝硬度（LS）值的变化趋势。进行了一项为期13年（2007 - 2019年）的回顾性研究，纳入了到我们诊所进行LS测量（LSM）的患者，这些患者要么患有已知肝病，要么有疑似肝脏病变且正在接受纤维化筛查。数据库中共有23420次测量。90.91%（21291/23420）的病例获得了有效的LSM，而2129次（9.09%）测量失败或不可靠。在未经治疗的慢性病毒性肝炎患者中，LS值多年来呈上升趋势，而在接受抗病毒治疗的患者中，LS值显著下降。我们这项全面的研究是此类研究中规模最大的之一，跨越13年，强调了VCTE在实际临床环境中的可靠性和重要性。
