Arabi Tarek Ziad, Algheryafi Linah Abdulmohsen, Alodah Nora A, Enabi Hamza M Kossai, Alshehry Amjad Abdullah, Ouban Abderrahman
College of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia.
Department of Pathology, College of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia.
Cancers (Basel). 2023 Aug 22;15(17):4208. doi: 10.3390/cancers15174208.
Head and neck carcinomas have been associated with poor prognosis. Recent studies have highlighted the role of claudins' expression in tumors throughout the body, and their prognostic and therapeutic role. Understanding the role of claudins and how their expression affects the progression of carcinomas in the head and neck region may allow for advances in the prognosis and management of this type of cancer. Several studies have highlighted the aberrant expression of the proteins in carcinomas in this region. Specifically, the overexpression of claudin-1 and downregulation of claudins-4, -7, and -17 have been linked with poor survival in oral squamous cell carcinoma patients. In laryngeal squamous cell carcinoma, increased levels of claudins-1 and reduced levels of claudins-3, -8, and -11 have been linked with poor outcomes. Targeting these proteins has shown promising outcomes as therapeutic in preclinical studies. However, studies remain extremely limited in nasal and hypopharyngeal carcinomas. In this review, we survey the available literature describing the aberrant expression of various claudins in carcinomas in this region, while highlighting their potential prognostic and therapeutic value. Then, we describe some molecular mechanisms involved in the aberrant expression of claudins and how they can be utilized as therapeutic targets.
头颈癌一直与预后不良相关。最近的研究强调了紧密连接蛋白在全身肿瘤中的表达作用，以及它们的预后和治疗作用。了解紧密连接蛋白的作用及其表达如何影响头颈区域癌的进展，可能会推动这类癌症预后和管理方面的进展。多项研究强调了该区域癌中这些蛋白的异常表达。具体而言，紧密连接蛋白-1的过表达以及紧密连接蛋白-4、-7和-17的下调与口腔鳞状细胞癌患者的不良生存相关。在喉鳞状细胞癌中，紧密连接蛋白-1水平升高以及紧密连接蛋白-3、-8和-11水平降低与不良预后相关。在临床前研究中，针对这些蛋白的治疗已显示出有前景的结果。然而，在鼻癌和下咽癌方面的研究仍然极为有限。在本综述中，我们调查了描述该区域癌中各种紧密连接蛋白异常表达的现有文献，同时强调它们潜在的预后和治疗价值。然后，我们描述了一些与紧密连接蛋白异常表达相关的分子机制，以及它们如何被用作治疗靶点。
