用于体内淀粉样斑块成像的双光子荧光探针。
Two-Photon Fluorescent Probes for Amyloid-β Plaques Imaging In Vivo.
机构信息
Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
School of Future Technology, University of Chinese Academy of Sciences, Beijing 100190, China.
出版信息
Molecules. 2023 Aug 22;28(17):6184. doi: 10.3390/molecules28176184.
Amyloid-β (Aβ) peptide deposition, hyperphosphorylated tau proteins, reactive astrocytes, high levels of metal ions, and upregulated monoamine oxidases are considered to be the primary pathological markers of Alzheimer's disease (AD). Among them, Aβ peptide deposition or Aβ plaques, is regarded as the initial factor in the pathogenesis of AD and a critical pathological hallmark in AD. This review highlights recently Aβ-specific fluorescent probes for two-photon imaging of Aβ plaques in vivo. It includes the synthesis and detection mechanism of probes, as well as their application to two-photon imaging of Aβ plaques in vivo.
淀粉样蛋白-β（Aβ）肽沉积、过度磷酸化的 tau 蛋白、反应性星形胶质细胞、高水平的金属离子和上调的单胺氧化酶被认为是阿尔茨海默病（AD）的主要病理标志物。其中，Aβ 肽沉积或 Aβ 斑块被认为是 AD 发病机制的初始因素，也是 AD 的关键病理标志。本综述重点介绍了最近用于体内 Aβ 斑块双光子成像的 Aβ 特异性荧光探针。它包括探针的合成和检测机制，以及它们在体内 Aβ 斑块双光子成像中的应用。
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