Department of Chemical Sciences, University of Naples "Federico II", I-80126 Naples, Italy.
Molecules. 2023 Aug 25;28(17):6237. doi: 10.3390/molecules28176237.
1,4-Benzothiazines are the main building blocks of the naturally occurring pheomelanin pigments, and their chromophoric properties have been strongly related to the well-known phototoxicity of these pigments, partly responsible for the high incidence of melanoma and other skin cancers in red-haired people. However, some peculiar features of the 1,4-benzothiazine chromophore could be functionally exploited in several sectors. Within this context, in this perspective, an overview of the very recently reported applications of the 1,4-benzothiazine chromophore in pH sensing, filter permeability control, smart packaging, electrochromic device fabrication, bioimaging, photocatalysis, and HPLC detection systems is provided, together with a brief presentation of recently developed synthetic approaches to the 1,4-benzothiazine scaffold, with the aim of emphasizing the still-undervalued multifunctional opportunities offered by this class of compounds.
1,4-苯并噻嗪是天然产生的真黑色素颜料的主要结构单元，其生色团的特性与这些颜料众所周知的光毒性密切相关，这在一定程度上导致红发人群黑色素瘤和其他皮肤癌的发病率较高。然而，1,4-苯并噻嗪生色团的一些特殊性质可以在多个领域得到功能利用。在这方面，本文综述了 1,4-苯并噻嗪生色团在 pH 传感、过滤通透性控制、智能包装、电致变色器件制造、生物成像、光催化和高效液相色谱检测系统中的最新报道应用，并简要介绍了最近开发的 1,4-苯并噻嗪骨架的合成方法，旨在强调这类化合物所提供的仍然被低估的多功能机会。
