Department of Geriatrics, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.
Biol Trace Elem Res. 2024 Jun;202(6):2410-2418. doi: 10.1007/s12011-023-03846-2. Epub 2023 Sep 9.
A growing number of observational studies have been carried out on the relationship between serum magnesium and risk of dyslipidemia, but their results were conflicting. This study aimed to investigate the association between serum magnesium levels and risk of dyslipidemia in Chinese adult residents. We used data from the China Health and Nutrition Survey (CHNS) in the wave of 2009 to conduct a cross-sectional study. A total of 8,457 participants (47.2% male) with a mean age of 50.5 years were assessed and divided into 4 groups based on quartiles of serum magnesium levels. We found that higher quartiles of serum magnesium were associated with increased prevalence of dyslipidemia. After adjustment for confounders, the results of logistic regression analyses indicated that there was an increased trend in dyslipidemia risk as quartiles of serum magnesium increased. The restricted cubic spline model revealed a nonlinear relationship between serum magnesium levels and dyslipidemia. In subgroup analyses, the positive relationship between serum magnesium levels and dyslipidemia was more significant in females than in males. Our study suggested that serum magnesium levels were positively associated with risk of dyslipidemia in Chinese adult population. Further research is needed to provide a deep understanding of the underlying mechanism of magnesium on lipid metabolism.
越来越多的观察性研究已经针对血清镁与血脂异常风险之间的关系展开，但它们的结果存在矛盾。本研究旨在探讨中国成年居民血清镁水平与血脂异常风险之间的关联。我们使用了中国健康与营养调查（CHNS）2009 年波次的数据进行了一项横断面研究。共有 8457 名参与者（47.2%为男性），平均年龄为 50.5 岁，根据血清镁水平的四分位间距将其分为 4 组。我们发现，血清镁水平较高的四分位数与血脂异常的患病率增加有关。在调整了混杂因素后，逻辑回归分析的结果表明，随着血清镁四分位数的增加，血脂异常的风险呈上升趋势。限制三次样条模型显示，血清镁水平与血脂异常之间存在非线性关系。在亚组分析中，血清镁水平与血脂异常之间的正相关关系在女性中比在男性中更为显著。我们的研究表明，血清镁水平与中国成年人群血脂异常的风险呈正相关。需要进一步的研究来深入了解镁对脂质代谢的潜在机制。
