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环境富集增强了老年大鼠中风后的神经发生和行为恢复。

Environmental enrichment enhanced neurogenesis and behavioral recovery after stroke in aged rats.

作者信息

Yan Ji, Liu Yan, Zheng Fangda, Lv Dan, Jin Di

机构信息

Department of Laboratory Medicine, The Fourth People’s Hospital of Shenyang of China Medical University, Shenyang, Liaoning, China.

Department of Neurology, The Fourth People’s Hospital of Shenyang of China Medical University, Shenyang, Liaoning, China.

出版信息

Aging (Albany NY). 2023 Sep 8;15(18):9453-9463. doi: 10.18632/aging.205010.

DOI:10.18632/aging.205010
PMID:37688770
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10564416/
Abstract

BACKGROUND AND PURPOSE

Age is identified as a significant prognostic factor for poorer outcome after stroke. However, environmental enrichment (EE) has been reported to promote functional recovery after ischemic stroke. The purpose of this study was to investigate whether environmental enrichment was beneficial to ischemic stroke in aged rats.

METHODS

Aged rats were randomly assigned as control rats, rats subjected to cerebral ischemia, and rats with cerebral ischemia treated with EE for 30 days. Focal cortical ischemia was induced by intracranial injection of endothelin-1 (ET-1). EE housing began one day after focal ischemia and was maintained for the whole experimental period. We used immunofluorescence staining to analyze the neurogenesis in the subventricular zone (SVZ) and TdT-mediated dUTP-biotin nick-end labeling (TUNEL) assay to evaluate apoptosis. The expression of neuronal nuclei, glial fibrillary acidic protein (GFAP) and Iba-1 around the infarcted area were also measured by double immunohistochemistry.

RESULTS

EE enhanced the proliferation of newborn neurons in the SVZ, as well as increased the long-term survival of newborn neurons. EE also exerted effects on inflammation after stroke. Furthermore, EE suppressed apoptosis and improved the motor functions after stroke in the aged rats.

CONCLUSIONS

EE improved post-stroke recovery on the basis of enhancing neurogenesis in aged rats.

摘要

背景与目的

年龄被认为是卒中后预后较差的一个重要预后因素。然而，据报道环境富集（EE）可促进缺血性卒中后的功能恢复。本研究的目的是探讨环境富集对老年大鼠缺血性卒中是否有益。

方法

将老年大鼠随机分为对照组、脑缺血大鼠组和脑缺血后接受30天环境富集处理的大鼠组。通过颅内注射内皮素-1（ET-1）诱导局灶性皮质缺血。环境富集饲养在局灶性缺血后一天开始，并持续整个实验期。我们使用免疫荧光染色分析脑室下区（SVZ）的神经发生，并采用TdT介导的dUTP生物素缺口末端标记（TUNEL）法评估细胞凋亡。还通过双重免疫组织化学检测梗死灶周围神经元细胞核、胶质纤维酸性蛋白（GFAP）和离子钙结合衔接分子1（Iba-1）的表达。

结果

环境富集增强了脑室下区新生神经元的增殖，同时增加了新生神经元的长期存活。环境富集对卒中后的炎症也有影响。此外，环境富集抑制了老年大鼠卒中后的细胞凋亡并改善了运动功能。

结论

环境富集在增强老年大鼠神经发生的基础上改善了卒中后的恢复。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5d7/10564416/351daad1fb24/aging-15-205010-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5d7/10564416/0593b467fa63/aging-15-205010-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5d7/10564416/52449518215f/aging-15-205010-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5d7/10564416/e33cccc4cc7d/aging-15-205010-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5d7/10564416/1b930d6744a9/aging-15-205010-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5d7/10564416/b9348c32bd1f/aging-15-205010-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5d7/10564416/351daad1fb24/aging-15-205010-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5d7/10564416/0593b467fa63/aging-15-205010-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5d7/10564416/52449518215f/aging-15-205010-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5d7/10564416/e33cccc4cc7d/aging-15-205010-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5d7/10564416/1b930d6744a9/aging-15-205010-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5d7/10564416/b9348c32bd1f/aging-15-205010-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5d7/10564416/351daad1fb24/aging-15-205010-g006.jpg

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Post-Stroke Environmental Enrichment Improves Neurogenesis and Cognitive Function and Reduces the Generation of Aberrant Neurons in the Mouse Hippocampus.卒中后环境丰富可改善神经发生和认知功能，并减少小鼠海马中异常神经元的产生。
Cells. 2023 Feb 17;12(4):652. doi: 10.3390/cells12040652.
3
Very early environmental enrichment protects against apoptosis and improves functional recovery from hypoxic-ischemic brain injury.
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Front Behav Neurosci. 2024 Dec 4;18:1501377. doi: 10.3389/fnbeh.2024.1501377. eCollection 2024.
极早期环境富集可防止细胞凋亡，并改善缺氧缺血性脑损伤后的功能恢复。
Front Mol Neurosci. 2023 Feb 7;15:1019173. doi: 10.3389/fnmol.2022.1019173. eCollection 2022.
4
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5
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6
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