Department of Pharmacy, Hebei General Hospital, Shijiazhuang, Hebei, China.
Department of Reproductive Genetics, Hebei General Hospital, Shijiazhuang, Hebei, China.
Diagn Microbiol Infect Dis. 2023 Nov;107(3):116047. doi: 10.1016/j.diagmicrobio.2023.116047. Epub 2023 Aug 2.
Current study aims to explore the correlation between the administered dose and efficacy of voriconazole in the treatment of invasive fungal infection (IFI). The correlation between different doses of Voriconazole and plasma concentrations as well as clinical efficacy was counted. Consequently, 40 strains of pathogenic micro-organisms were isoninelated and cultured from etiological samples. A total of 66 patients with steady-state trough serum concentrations ranging from 1.0 to 5.5 μg/mL were measured, with a compliance rate of 79.5%. Chi-square test showed that there was a significant correlation between Voriconazole steady-state serum trough concentration and treatment efficacy. In addition, the result of Pearson test showed that steady-state trough serum concentration of Voriconazole was significantly positively correlated with the administered dose (γ = 0.866, P < 0.001). On conclusion, Voriconazole is effective in treatment of IFI, and there is a significant dose-plasma concentration correlation with efficacy.
本研究旨在探讨伏立康唑给药剂量与侵袭性真菌感染（IFI）疗效之间的相关性。对伏立康唑不同剂量与血药浓度及临床疗效的相关性进行了统计。从病因学样本中分离培养了 40 株病原菌。共测量了 66 例稳态谷浓度在 1.0 至 5.5μg/ml 之间的患者，依从率为 79.5%。卡方检验显示伏立康唑稳态血清谷浓度与治疗效果之间存在显著相关性。此外，皮尔逊检验结果表明伏立康唑稳态血清谷浓度与给药剂量呈显著正相关（γ=0.866，P<0.001）。结论：伏立康唑治疗 IFI 有效，且与疗效具有显著的剂量-血药浓度相关性。
