Weisberg M
Clin Ther. 1986;8(5):563-7.
Pregnancy creates a climate favorable to the growth of Candida albicans, and this yeast often is difficult to eradicate in pregnant women. Miconazole nitrate administered intravaginally has been found to achieve comparable therapeutic and mycological cure rates in both pregnant and nonpregnant women. A number of clinical studies, using rigid definitions of cure, have demonstrated that miconazole nitrate is significantly better than nystatin, clotrimazole, and butoconazole, a new imidazole derivative, in treating vaginal candidiasis during gestation.
怀孕会营造出有利于白色念珠菌生长的环境，而且这种酵母菌在孕妇体内往往难以根除。已发现经阴道给药的硝酸咪康唑在孕妇和非孕妇中能达到相当的治疗和真菌学治愈率。多项临床研究采用严格的治愈定义，结果表明，在治疗妊娠期阴道念珠菌病方面，硝酸咪康唑显著优于制霉菌素、克霉唑以及一种新型咪唑衍生物布康唑。
