Schäfer E, Maurer-Schultze B
Cell Tissue Kinet. 1986 Jul;19(4):437-47. doi: 10.1111/j.1365-2184.1986.tb00741.x.
Cyclophosphamide (CY) does not act in a cell-cycle specific manner, i.e. exclusively on proliferating cells. It also kills non-proliferating cells, as shown by application of CY to L 1210 ascites tumour-bearing mice during plateau phase growth of the tumour. Moreover, treatment with CY of L 1210 ascites tumour cells, double-labelled with [3H] and [14C]-thymidine, suggests that CY is not cell cycle phase dependent, but kills cells out of all cycle phases. There is also an extensive cytocidal effect of CY (300 mg/kg) on the jejunal crypt cells of the mouse, which is even more pronounced than that of cisplatinum (DDP, 13 mg/kg). However, rapid regeneration of crypt cells occurs after treatment with the drugs.
环磷酰胺（CY）并非以细胞周期特异性方式起作用，即并非仅作用于增殖细胞。它也会杀死非增殖细胞，如在肿瘤平台期生长期间将CY应用于携带L 1210腹水瘤的小鼠所显示的那样。此外，用CY处理经[3H]和[14C] - 胸腺嘧啶双标记的L 1210腹水瘤细胞表明，CY不依赖于细胞周期阶段，而是杀死所有周期阶段的细胞。CY（300mg/kg）对小鼠空肠隐窝细胞也有广泛的杀细胞作用，甚至比顺铂（DDP，13mg/kg）更明显。然而，用药后隐窝细胞会迅速再生。
