Chlumská A
Cesk Patol. 1986 Aug;22(3):158-64.
The elevation of intraductal bile pressure in hepatic tissue of rats manifested itself a few hours later the ligation of common bile duct by focal dilatation of bile canaliculi which was followed by proceeding concentration of pericanalicular ectoplasma of hepatocytes and partial renewal of contractility of canalicular system. Later, proliferation of interlobular bile ducts together with a relatively rapid loss of pericanalicular density followed. New - built bile ducts scarcely infiltrated by polynuclear leucocytes proceeded from margins of portal tracts in between trabecules of hepatocytes in the periphery of lobules.
大鼠肝组织内胆管压力升高在胆总管结扎数小时后表现为胆小管局灶性扩张,随后肝细胞膜周胞浆浓缩,胆小管系统收缩性部分恢复。之后,小叶间胆管增生,同时膜周密度相对快速降低。新生胆管几乎没有多形核白细胞浸润,从门静脉周围在小叶周边肝细胞小梁之间延伸。