Department of Anesthesiology and Perioperative Care, Veterinary University of Vienna, Vienna, Austria.
Anaesthesia Section, School of Veterinary Science, Massey University, University Avenue, Palmerston North 4472, New Zealand.
Vet Anaesth Analg. 2023 Nov;50(6):498-501. doi: 10.1016/j.vaa.2023.06.005. Epub 2023 Jul 17.
To retrospectively evaluate the feasibility of a propofol infusion for anaesthetic maintenance in guinea pigs.
Retrospective case series.
Client-owned guinea pigs undergoing general anaesthesia.
Anaesthetic records of guinea pigs anaesthetized between March 2015 and March 2018 were reviewed. Animals administered a propofol infusion for > 20 minutes were identified and evaluated. Procedure performed, pre-anaesthetic medication, preoperative and intraoperative respiratory rate (f) and heart rates (HRs), total amount of propofol administered, total anaesthesia and recovery times were extracted from the records and analysed using descriptive statistics and Pearson correlation tests. Data are reported as mean (range).
Records of 14 animals meeting the criteria were identified. Following drug combinations were administered for premedication: butorphanol 0.43 (0.3-0.5) mg kg, medetomidine 0.1 (0.05-0.2) mg kg and midazolam 1 (0.5-2) mg kg (n = 3); methadone 0.33 (0.25-0.5) mg kg, medetomidine 0.07 (0.01-0.1) mg kg and midazolam 0.66 (0.5-1) mg kg (n = 3); butorphanol 0.5 mg kg, medetomidine 0.05 mg kg and ketamine 5 mg kg (n = 2); buprenorphine 0.01 mg kg, medetomidine 0.07 (0.04-1) mg kg and ketamine 4 (3-5) mg kg (n = 3); butorphanol 0.5 mg kg, alfaxalone 1 mg kg and midazolam 0.5 mg kg (n = 1); and methadone 0.38 (0.25-0.5) mg kg, medetomidine 0.08 (0.06-1) mg kg with midazolam 0.75 (0.5-1) mg kg (n = 2). Preoperative and intraoperative HRs were 240 (160-300) and 170 (140-200) beats minute, respectively. Preoperative and intraoperative f were 63 (50-86) and 37 (18-80) breaths minute, respectively. The propofol infusion rate was 0.45 (0.17-0.80) mg kg minute. Total anaesthesia and recovery times were 60 (25-145) and 17 (8-60) minutes, respectively. A slight correlation was found between total propofol dose infused and recovery time (r = 0.58).
Propofol infusions may be a useful alternative to inhalant anaesthetics.
回顾性评估豚鼠中异丙酚输注用于麻醉维持的可行性。
回顾性病例系列。
接受全身麻醉的患畜豚鼠。
回顾了 2015 年 3 月至 2018 年 3 月间接受全身麻醉的豚鼠的麻醉记录。确定并评估了接受异丙酚输注超过 20 分钟的动物。从记录中提取并分析了进行的程序、术前用药、术前和术中的呼吸频率（f）和心率（HRs）、给予的异丙酚总量、总麻醉和恢复时间，并使用描述性统计和 Pearson 相关检验进行分析。数据以平均值（范围）表示。
确定了符合标准的 14 只动物的记录。以下是用于预处理的药物组合：丁丙诺啡 0.43（0.3-0.5）mg/kg、美托咪定 0.1（0.05-0.2）mg/kg 和咪达唑仑 1（0.5-2）mg/kg（n=3）；美沙酮 0.33（0.25-0.5）mg/kg、美托咪定 0.07（0.01-0.1）mg/kg 和咪达唑仑 0.66（0.5-1）mg/kg（n=3）；丁丙诺啡 0.5mg/kg、美托咪定 0.05mg/kg 和氯胺酮 5mg/kg（n=2）；布托啡诺 0.01mg/kg、美托咪定 0.07（0.04-1）mg/kg 和氯胺酮 4（3-5）mg/kg（n=3）；丁丙诺啡 0.5mg/kg、阿法沙龙 1mg/kg 和咪达唑仑 0.5mg/kg（n=1）；以及美沙酮 0.38（0.25-0.5）mg/kg、美托咪定 0.08（0.06-1）mg/kg 加咪达唑仑 0.75（0.5-1）mg/kg（n=2）。术前和术中 HR 分别为 240（160-300）和 170（140-200）次/分钟。术前和术中 f 分别为 63（50-86）和 37（18-80）次/分钟。异丙酚输注率为 0.45（0.17-0.80）mg/kg/min。总麻醉和恢复时间分别为 60（25-145）和 17（8-60）分钟。总注入的异丙酚剂量与恢复时间之间存在轻微相关性（r=0.58）。
异丙酚输注可能是吸入麻醉的一种有用替代方法。
