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肝移植候选者的冠状动脉疾病筛查方法:文献综述。

Screening Modalities for Coronary Artery Disease in Liver Transplant Candidates: A Review of the Literature.

机构信息

Department of Gastroenterology, University of Maryland Medical Center, Baltimore, MD.

Department of Gastroenterology, Hepatology and Nutrition, Cleveland Clinic, Cleveland, OH; Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH.

出版信息

J Cardiothorac Vasc Anesth. 2023 Dec;37(12):2611-2620. doi: 10.1053/j.jvca.2023.08.126. Epub 2023 Aug 13.

Abstract

Patients with cirrhosis undergoing liver transplant (LT) are at high risk of postoperative cardiopulmonary complications. It is known that patients with coronary artery disease (CAD) have greater rates of post-LT morbidity and mortality than patients without CAD. Thus, identifying significant CAD in LT candidates is of the utmost importance to optimize survival posttransplant. Consensus is lacking on the ideal screening test for CAD in LT candidates. Traditional exercise and many pharmacologic stress tests are impractical and inaccurate in patients with cirrhosis due to their unique physiology. The purpose of this review is to describe different screening modalities for CAD among LT candidates. The background, diagnostic accuracy, and limitations of each screening modality are described to achieve this goal.

摘要

接受肝移植 (LT) 的肝硬化患者术后心肺并发症的风险很高。众所周知,患有冠状动脉疾病 (CAD) 的患者比没有 CAD 的患者在 LT 后发病率和死亡率更高。因此,确定 LT 候选者是否存在显著 CAD 对于优化移植后的生存率至关重要。对于 LT 候选者的 CAD 理想筛查试验,目前尚未达成共识。由于肝硬化患者的独特生理状况,传统的运动和许多药物负荷试验在这些患者中不切实际且不准确。本综述的目的是描述 LT 候选者中 CAD 的不同筛查方式。描述了每种筛查方式的背景、诊断准确性和局限性,以实现这一目标。

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