Liao Xiaolin, Han Yuanshan, Shen Chuanpu, Liu Jianjun, Wang Yuhong
Institute of Innovation and Applied Research in Chinese Medicine, Hunan University of Chinese Medicine, Changsha, China.
Scientific Research Department, The First Hospital of Hunan University of Chinese Medicine, Changsha, China.
Phytother Res. 2023 Dec;37(12):5622-5638. doi: 10.1002/ptr.8009. Epub 2023 Sep 10.
Hypertension is a major global health problem that causes target organ damage (TOD) in the heart, brain, kidney, and blood vessels. The mechanisms of hypertensive TOD are not fully understood, and its treatment is challenging. This review provides an overview of the current knowledge on the role of Nod-like receptor pyrin domain containing 3 (NLRP3) inflammasome in hypertensive TOD and the natural products and formulations that inhibit it.
We searched PubMed, Web of Science, Google Scholar, and CNKI for relevant articles using the keywords "hypertension," "target organ damage," "NLRP3 inflammasome," "natural products," and "formulations." We reviewed the effects of the NLRP3 inflammasome on hypertensive TOD in different organs and discussed the natural products and formulations that modulate it.
In hypertensive TOD, the NLRP3 inflammasome is activated by various stimuli such as oxidative stress and inflammation. Activation of NLRP3 inflammasome leads to the production of pro-inflammatory cytokines that exacerbate tissue damage and dysfunction. Natural products and formulations, including curcumin, resveratrol, triptolide, and allicin, have shown protective effects against hypertensive TOD by inhibiting the NLRP3 inflammasome.
The NLRP3 inflammasome is a promising therapeutic target in hypertensive TOD. Natural products and formulations that inhibit the NLRP3 inflammasome may provide novel drug candidates or therapies for hypertensive TOD. Further studies are needed to elucidate the molecular mechanisms and optimize the dosages of these natural products and formulations and evaluate their clinical efficacy and safety.
高血压是一个重大的全球健康问题，可导致心脏、大脑、肾脏和血管的靶器官损害（TOD）。高血压性TOD的机制尚未完全明确，其治疗具有挑战性。本综述概述了目前关于含NOD样受体吡咯结构域蛋白3（NLRP3）炎性小体在高血压性TOD中的作用以及抑制它的天然产物和制剂的相关知识。
我们在PubMed、科学网、谷歌学术和中国知网中使用关键词“高血压”“靶器官损害”“NLRP3炎性小体”“天然产物”和“制剂”搜索相关文章。我们综述了NLRP3炎性小体对不同器官高血压性TOD的影响，并讨论了调节它的天然产物和制剂。
在高血压性TOD中，NLRP3炎性小体被氧化应激和炎症等各种刺激激活。NLRP3炎性小体的激活导致促炎细胞因子的产生，加剧组织损伤和功能障碍。包括姜黄素、白藜芦醇、雷公藤内酯醇和大蒜素在内的天然产物和制剂已显示出通过抑制NLRP3炎性小体对高血压性TOD具有保护作用。
NLRP3炎性小体是高血压性TOD中一个有前景的治疗靶点。抑制NLRP3炎性小体的天然产物和制剂可能为高血压性TOD提供新的候选药物或治疗方法。需要进一步研究以阐明这些天然产物和制剂的分子机制并优化其剂量，并评估其临床疗效和安全性。
