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暴露于12-O-十四酰佛波醇-13-乙酸酯的C3H/10T1/2小鼠胚胎培养物中形态转化的可逆表达。

Reversible expression of morphological transformation in C3H/10T1/2 mouse embryo cultures exposed to 12-O-tetradecanoylphorbol-13-acetate.

作者信息

Sanchez J H, Abernethy D J, Boreiko C J

出版信息

Carcinogenesis. 1986 Nov;7(11):1793-6. doi: 10.1093/carcin/7.11.1793.

DOI:10.1093/carcin/7.11.1793
PMID:3769129
Abstract

Treatment of C3H/10T1/2 mouse embryo fibroblasts with N-methyl-N'-nitro-N-nitrosoguanidine and then 12-O-tetradecanoylphorbol-13-acetate (TPA) resulted in the production of numerous foci of morphologically transformed cells. When dishes containing foci were provided medium which did not contain TPA, up to 84% of the foci were found to regress. Promotion of morphological transformation by TPA in C3H/10T1/2 cells may thus be a reversible process.

摘要

用N-甲基-N'-硝基-N-亚硝基胍处理C3H/10T1/2小鼠胚胎成纤维细胞，然后用12-O-十四烷酰佛波醇-13-乙酸酯（TPA）处理，导致产生大量形态转化细胞灶。当向含有细胞灶的培养皿中提供不含TPA的培养基时，发现高达84%的细胞灶会消退。因此，TPA对C3H/10T1/2细胞形态转化的促进作用可能是一个可逆过程。

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