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2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) promotes the transformation of C3H/10T1/2 cells.

作者信息

Abernethy D J, Greenlee W F, Huband J C, Boreiko C J

出版信息

Carcinogenesis. 1985 Apr;6(4):651-3. doi: 10.1093/carcin/6.4.651.

DOI:10.1093/carcin/6.4.651
PMID:3986969
Abstract

Continuous treatment of C3H/10T1/2 cells with low concentrations (greater than or equal to 4 pM) of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) enhanced focus production in cultures pretreated with N-methyl-N'-nitro-N-nitrosoguanidine. Maximal enhancement occurred at 40 pM TCDD, a concentration 10 000-fold lower than that required to produce an optimal response with 12-O-tetradecanoylphorbol-13-acetate. Single treatments with 0.06 nM-5 microM TCDD did not transform C3H/10T1/2 cells or initiate the process of transformation in cultures subsequently exposed to the tumor promoter 12-O-tetradecanoylphorbol-13-acetate. Promotion of transformation is thus the predominant effect of TCDD in the C3H/101/2 cell transformation system.

摘要

相似文献

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引用本文的文献

1
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2
Polyhalogenated dibenzo-p-dioxins and dibenzofurans and the immune system. 2. In vitro effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on lymphocytes of venous blood from man and a non-human primate (Callithrix jacchus).多卤代二苯并 - 对 - 二恶英和二苯并呋喃与免疫系统。2. 2,3,7,8 - 四氯二苯并 - 对 - 二恶英（TCDD）对人及非人灵长类动物（狨猴）静脉血淋巴细胞的体外作用。
Arch Toxicol. 1991;65(3):213-9. doi: 10.1007/BF02307311.