University of Tunis El Manar, Tunis, Tunisia.
Pneumology, Military Hospital of Tunis, Tunis, 1008, Tunisia.
F1000Res. 2023 Sep 5;12:337. doi: 10.12688/f1000research.130939.2. eCollection 2023.
Idiopathic chronic eosinophilic pneumonia (ICEP) is a rare interstitial lung disease of unknown cause. It usually responds well to systemic corticosteroid therapy, but relapses are frequent. We describe two cases of 21- and 27-year-old patients, presenting with dyspnea. The diagnosis of steroid-relapsing and steroid-dependent ICEP was made respectively. Mepolizumab was prescribed to both patients. This treatment resulted in successful long-term disease management with much fewer side effects than a traditional corticosteroid therapy.
特发性慢性嗜酸性粒细胞性肺炎（ICEP）是一种病因不明的罕见间质性肺疾病。它通常对全身皮质类固醇治疗反应良好，但复发频繁。我们描述了两例分别为 21 岁和 27 岁的患者，表现为呼吸困难。诊断为激素复发和激素依赖的 ICEP。 为两名患者都开了美泊利珠单抗。与传统的皮质类固醇治疗相比，这种治疗在减少副作用的情况下成功地进行了长期疾病管理。
