Fu Longsheng, Zou Yonghui, Yu Boyang, Hong Daojun, Guan Teng, Hu Jinfang, Xu Yi, Wu Yaoqi, Kou Junping, Lv Yanni
Department of Pharmacy, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Jiangsu Key Laboratory of TCM Evaluation and Translational Research, Department of Pharmacology of Chinese Materia Medica, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, Jiangxi, China.
Front Cell Dev Biol. 2023 Aug 23;11:1220672. doi: 10.3389/fcell.2023.1220672. eCollection 2023.
The myosin superfamily is a group of molecular motors. Autoimmune diseases are characterized by dysregulation or deficiency of the immune tolerance mechanism, resulting in an immune response to the human body itself. The link between myosin and autoimmune diseases is much more complex than scientists had hoped. Myosin itself immunization can induce experimental autoimmune diseases of animals, and myosins were abnormally expressed in a number of autoimmune diseases. Additionally, myosin takes part in the pathological process of multiple sclerosis, Alzheimer's disease, Parkinson's disease, autoimmune myocarditis, myositis, hemopathy, inclusion body diseases, etc. However, research on myosin and its involvement in the occurrence and development of diseases is still in its infancy, and the underlying pathological mechanisms are not well understood. We can reasonably predict that myosin might play a role in new treatments of autoimmune diseases.
肌球蛋白超家族是一组分子马达。自身免疫性疾病的特征是免疫耐受机制失调或缺陷，导致对人体自身产生免疫反应。肌球蛋白与自身免疫性疾病之间的联系比科学家们所期望的要复杂得多。肌球蛋白自身免疫可诱导动物实验性自身免疫性疾病，并且在多种自身免疫性疾病中肌球蛋白表达异常。此外，肌球蛋白参与多发性硬化症、阿尔茨海默病、帕金森病、自身免疫性心肌炎、肌炎、血液病、包涵体病等的病理过程。然而，关于肌球蛋白及其在疾病发生发展中的作用的研究仍处于起步阶段，其潜在的病理机制尚未完全明确。我们可以合理预测，肌球蛋白可能在自身免疫性疾病的新治疗中发挥作用。
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