• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

聚焦消融疗法为局限性前列腺癌患者带来了有前景的治疗效果。

Focal ablation therapy presents promising results for selectively localized prostate cancer patients.

作者信息

Feng Dechao, Li Dengxiong, Xiao Yuhan, Wu Ruicheng, Wang Jie, Zhang Chi

机构信息

Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China.

Department of Rehabilitation, the Affiliated Hospital of Southwest Medical University, Luzhou 646000, China.

出版信息

Chin J Cancer Res. 2023 Aug 30;35(4):424-430. doi: 10.21147/j.issn.1000-9604.2023.04.08.

DOI:10.21147/j.issn.1000-9604.2023.04.08
PMID:37691892
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10485919/
Abstract

Due to its lower risk of consequences when compared to a radical approach, focal treatment is a viable and minimally invasive option for treating specific localized prostate cancer. Although several recent good non-randomized trials have suggested that focused therapy may be an alternative choice for some patients, additional high-quality evidence is needed before it can be made widely available as a conventional treatment. As a result, we have summarized the most recent findings from the 38th Annual European Association of Urology Congress, one of the most renowned annual conferences in the area of urology, regarding focal ablation therapy for patients with localized prostate cancer. Additionally, we also provided clinical trials in progress for researchers to better understand the current research status of this field.

摘要

与根治性治疗方法相比,聚焦治疗导致不良后果的风险较低,因此是治疗特定局限性前列腺癌的一种可行且微创的选择。尽管最近有几项良好的非随机试验表明聚焦治疗可能是一些患者的替代选择,但在其能够作为常规治疗广泛应用之前,还需要更多高质量的证据。因此,我们总结了第38届欧洲泌尿外科学会年会(这是泌尿外科学领域最著名的年度会议之一)中关于局限性前列腺癌患者聚焦消融治疗的最新研究结果。此外,我们还提供了正在进行的临床试验,以便研究人员更好地了解该领域的当前研究状况。

相似文献

1
Focal ablation therapy presents promising results for selectively localized prostate cancer patients.聚焦消融疗法为局限性前列腺癌患者带来了有前景的治疗效果。
Chin J Cancer Res. 2023 Aug 30;35(4):424-430. doi: 10.21147/j.issn.1000-9604.2023.04.08.
2
An Updated Systematic Review on Focal Therapy in Localized Prostate Cancer: What Has Changed over the Past 5 Years?局限性前列腺癌聚焦治疗的最新系统评价:过去5年有哪些变化?
Eur Urol. 2022 Jan;81(1):5-33. doi: 10.1016/j.eururo.2021.08.005. Epub 2021 Sep 4.
3
Current evidence for focal therapy and partial gland ablation for organ-confined prostate cancer: systematic review of literature published in the last 2 years.目前有针对局限性前列腺癌的焦点治疗和部分腺体消融的证据:对过去 2 年发表的文献进行系统回顾。
Curr Opin Urol. 2021 Jan;31(1):49-57. doi: 10.1097/MOU.0000000000000838.
4
New treatments for localized prostate cancer.局限性前列腺癌的新疗法。
Urology. 2008 Dec;72(6 Suppl):S36-43. doi: 10.1016/j.urology.2008.08.506.
5
Focal Minimally Invasive Treatment in Localized Prostate Cancer: Comprehensive Review of Different Possible Strategies.局限性前列腺癌的局部微创治疗:不同可能策略的综合综述
Cancers (Basel). 2024 Feb 13;16(4):765. doi: 10.3390/cancers16040765.
6
[Laser in prostate cancer. Applicability.].[激光在前列腺癌中的应用。适用性。]
Arch Esp Urol. 2020 Oct;73(8):724-734.
7
High-intensity focused ultrasound as focal therapy of prostate cancer.高强度聚焦超声作为前列腺癌的焦点治疗。
Curr Opin Urol. 2014 May;24(3):225-30. doi: 10.1097/MOU.0000000000000053.
8
Focal therapy in the management of prostate cancer: an emerging approach for localized prostate cancer.前列腺癌治疗中的聚焦疗法:一种针对局限性前列腺癌的新兴方法。
Adv Urol. 2012;2012:391437. doi: 10.1155/2012/391437. Epub 2012 Apr 24.
9
Ablation energies for focal treatment of prostate cancer.前列腺癌病灶治疗的消融能量。
World J Urol. 2019 Mar;37(3):409-418. doi: 10.1007/s00345-018-2364-x. Epub 2018 Jun 25.
10
Focal therapy in prostate cancer: the current situation.前列腺癌的聚焦治疗:现状
Ecancermedicalscience. 2014 Jun 10;8:435. doi: 10.3332/ecancer.2014.435. eCollection 2014.

引用本文的文献

1
Functional characterization and clinical significance of IGSF8 in pan-cancer: an integrated bioinformatic and experimental study.IGSF8在泛癌中的功能表征及临床意义:一项综合生物信息学与实验研究
Front Immunol. 2025 Aug 27;16:1642193. doi: 10.3389/fimmu.2025.1642193. eCollection 2025.
2
Genetic alterations of prostate cancer: in localized and metastatic prostate cancer.前列腺癌的基因改变:局限期和转移期前列腺癌
BMC Urol. 2025 Jul 14;25(1):166. doi: 10.1186/s12894-025-01840-5.
3
Geriatric Nutritional Risk Index (GNRI) and Prognostic Nutritional Index (PNI) Before Treatment as the Predictive Indicators for Bone Metastasis in Prostate Cancer Patients.老年营养风险指数(GNRI)和治疗前预后营养指数(PNI)作为前列腺癌患者骨转移的预测指标
Int J Gen Med. 2025 May 24;18:2703-2713. doi: 10.2147/IJGM.S516768. eCollection 2025.
4
MicroRNA-18b-5p Inhibits the Malignant Progression of Prostate Cancer Through Downregulating TRAF5.微小RNA-18b-5p通过下调TRAF5抑制前列腺癌的恶性进展。
Int J Gen Med. 2025 Mar 31;18:1831-1843. doi: 10.2147/IJGM.S494962. eCollection 2025.
5
Exploring the positive association of blood lipid levels with prostate cancer risk and their relationship to pathological features in the Chinese population.探讨中国人群血脂水平与前列腺癌风险的正相关及其与病理特征的关系。
Medicine (Baltimore). 2025 Mar 21;104(12):e41762. doi: 10.1097/MD.0000000000041762.
6
Integrated analysis of single-cell and bulk transcriptomes uncovers clinically relevant molecular subtypes in human prostate cancer.单细胞和整体转录组的综合分析揭示了人类前列腺癌中与临床相关的分子亚型。
Chin J Cancer Res. 2025 Jan 30;37(1):90-114. doi: 10.21147/j.issn.1000-9604.2025.01.07.
7
A preliminary follow-up study on irreversible electroporation therapy in older patients with prostate cancer.老年前列腺癌患者不可逆电穿孔治疗的初步随访研究。
Discov Oncol. 2025 Mar 7;16(1):278. doi: 10.1007/s12672-025-02025-0.
8
Tracing the Evolution of Sex Hormones and Receptor-Mediated Immune Microenvironmental Differences in Prostate and Bladder Cancers: From Embryonic Development to Disease.追踪前列腺癌和膀胱癌中性激素的演变以及受体介导的免疫微环境差异:从胚胎发育到疾病
Adv Sci (Weinh). 2025 Apr;12(13):e2407715. doi: 10.1002/advs.202407715. Epub 2025 Feb 25.
9
Microbiota and urinary tumor immunity: Mechanisms, therapeutic implications, and future perspectives.微生物群与泌尿系统肿瘤免疫:机制、治疗意义及未来展望
Chin J Cancer Res. 2024 Dec 30;36(6):596-615. doi: 10.21147/j.issn.1000-9604.2024.06.03.
10
Association of serum steroids with survival in metastatic hormone-sensitive prostate cancer.血清类固醇与转移性激素敏感性前列腺癌生存率的关联
Endocr Relat Cancer. 2025 Jan 10;32(2). doi: 10.1530/ERC-24-0140. Print 2025 Feb 1.

本文引用的文献

1
Mutations in epigenetic regulator detected by liquid biopsy are associated with worse survival in prostate cancer patients.液体活检检测到的表观遗传调控因子突变与前列腺癌患者的生存预后较差相关。
Oncol Res. 2023 Jun 27;31(4):605-614. doi: 10.32604/or.2023.028321. eCollection 2023.
2
Dissecting the effects of androgen deprivation therapy on cadherin switching in advanced prostate cancer: A molecular perspective.剖析雄激素剥夺疗法对晚期前列腺癌钙黏蛋白转换的影响:分子视角。
Oncol Res. 2023 Jan 12;30(3):137-155. doi: 10.32604/or.2022.026074. eCollection 2022.
3
Melatonin and Prostate Cancer: Anti-tumor Roles and Therapeutic Application.褪黑素与前列腺癌:抗肿瘤作用及治疗应用
Aging Dis. 2023 Jun 1;14(3):840-857. doi: 10.14336/AD.2022.1010.
4
Comments on .关于……的评论
Chin J Cancer Res. 2022 Oct 30;34(5):456-457. doi: 10.21147/j.issn.1000-9604.2022.05.05.
5
Focal Therapy of Prostate Cancer Index Lesion With Irreversible Electroporation. A Prospective Study With a Median Follow-up of 3 Years.不可逆电穿孔对前列腺癌指数病灶的聚焦治疗。一项中位随访3年的前瞻性研究。
J Urol. 2023 Jan;209(1):261-270. doi: 10.1097/JU.0000000000002970. Epub 2022 Sep 8.
6
National guidelines for diagnosis and treatment of prostate cancer 2022 in China (English version).《中国2022年前列腺癌诊疗国家指南》(英文版)
Chin J Cancer Res. 2022 Jun 30;34(3):270-288. doi: 10.21147/j.issn.1000-9604.2022.03.07.
7
Extended Focal Ablation of Localized Prostate Cancer With High-Frequency Irreversible Electroporation: A Nonrandomized Controlled Trial.高频不可逆电穿孔治疗局限性前列腺癌的扩展焦点消融:一项非随机对照试验。
JAMA Surg. 2022 Aug 1;157(8):693-700. doi: 10.1001/jamasurg.2022.2230.
8
A gene prognostic index from cellular senescence predicting metastasis and radioresistance for prostate cancer.一个源于细胞衰老的基因预后指数,可预测前列腺癌的转移和放射抵抗。
J Transl Med. 2022 Jun 3;20(1):252. doi: 10.1186/s12967-022-03459-8.
9
PSMA-PET- and MRI-Based Focal Dose Escalated Radiation Therapy of Primary Prostate Cancer: Planned Safety Analysis of a Nonrandomized 2-Armed Phase 2 Trial (ARO2020-01).基于 PSMA-PET 和 MRI 的原发性前列腺癌焦点剂量递增放射治疗:一项非随机 2 臂 2 期试验(ARO2020-01)的计划安全性分析。
Int J Radiat Oncol Biol Phys. 2022 Aug 1;113(5):1025-1035. doi: 10.1016/j.ijrobp.2022.04.020. Epub 2022 Apr 22.
10
Energy Metabolism-Related Gene Prognostic Index Predicts Biochemical Recurrence for Patients With Prostate Cancer Undergoing Radical Prostatectomy.能量代谢相关基因预后指数预测接受根治性前列腺切除术的前列腺癌患者的生化复发。
Front Immunol. 2022 Feb 24;13:839362. doi: 10.3389/fimmu.2022.839362. eCollection 2022.