Al-Shammari Ahmed Hamza, Abbood Zainab A, Lateef Hayder F
Department of Pharmacy, Kut University College, Al-Kut, Wasit, Iraq.
Ministry of Health and Environment, Al-Zahraa Teaching Hospital, Al-Kut, Wasit, Iraq.
J Adv Pharm Technol Res. 2023 Jul-Sep;14(3):226-228. doi: 10.4103/JAPTR.JAPTR_225_23. Epub 2023 Jul 28.
Fatigue is a prevalent symptom experienced by individuals diagnosed with multiple sclerosis (MS), which greatly affects their daily activities and causes frustration and depression, thus affecting their lives and society. This can be prevented through the use of medicines such as L-carnitine and modafinil. The study aimed to examine the effect of L-carnitine and modafinil on fatigue and which one is better for MS patients. This was a clinical trial. This clinical trial was conducted in cooperation between Al-Kut University College and an MS consultant at Al-Zahraa Teaching Hospital in addition to the private neurological clinic from October 1, 2022, to March 15, 2023. Forty participants were split into two groups; both of which were almost identical characteristics regarding age, disease duration, and degree of fatigue. Group I ( = 20): relapsing-remitting MS patients with fatigue received modafinil. Group II ( = 20): relapsing-remitting MS patients with fatigue received L-carnitine. Fatigue was evaluated according to the Modified Fatigue Impact Scale (MFIS). The statistical work was done in SPSS (IBM Corp., Chicago, IL, USA, version 24). values were calculated by the -test. Significant data have = 0.05. After 2 months of treatment, the results show a significant decrease in MFIS in both groups with a higher reduction in patients who use L-carnitine. Both modafinil and L-carnitine show a significant influence on fatigue in MS patients, and these effects are more in L-carnitine.
疲劳是多发性硬化症（MS）患者普遍存在的症状，这极大地影响了他们的日常活动，并导致沮丧和抑郁，进而影响他们的生活和社会。这可以通过使用如左旋肉碱和莫达非尼等药物来预防。该研究旨在检验左旋肉碱和莫达非尼对疲劳的影响，以及哪一种对MS患者更好。这是一项临床试验。该临床试验于2022年10月1日至2023年3月15日在库特大学学院与扎赫拉教学医院的一位MS顾问以及一家私人神经诊所合作开展。40名参与者被分为两组；两组在年龄、病程和疲劳程度方面的特征几乎相同。第一组（n = 20）：患有疲劳的复发缓解型MS患者服用莫达非尼。第二组（n = 20）：患有疲劳的复发缓解型MS患者服用左旋肉碱。根据改良疲劳影响量表（MFIS）评估疲劳情况。统计工作在SPSS（美国伊利诺伊州芝加哥市IBM公司，版本24）中完成。P值通过t检验计算。显著数据的P = 0.05。治疗2个月后，结果显示两组的MFIS均显著下降，服用左旋肉碱的患者下降幅度更大。莫达非尼和左旋肉碱对MS患者的疲劳均有显著影响，且左旋肉碱的影响更大。
