Department of Neurology, Fundacion Jimenez Diaz, Madrid, Spain.
Department of Genetics, Fundacion Jimenez Diaz, Madrid, Spain.
Tremor Other Hyperkinet Mov (N Y). 2023 Sep 7;13:33. doi: 10.5334/tohm.800. eCollection 2023.
Chorea can have a wide variety of causes including neurodegenerative, pharmacological, structural, metabolic, infectious, immunologic and paraneoplastic processes. We reviewed the clinical records of patients with apparently sporadic choreic movements and no relevant family history, who presented to our neurology department (Hospital Fundación Jimenez Diaz) between 1991 and 2022. We detected 38 cases of apparent sporadic chorea (ASC); Our analysis revealed 5 cases of genetic chorea (including 3 cases with Huntington's disease) while 6 cases were autoimmune/hematological; 6 drug-related chorea, 5 metabolic-vascular, 5 due to miscellaneous conditions and 4 were of mixed etiology. No clear etiology was identified in 8 cases. The differential diagnosis of ASC is extensive and challenging.
Chorea can have a wide variety of genetic and sporadic causesWe reviewed the clinical records of patients with apparently sporadic chorea (ASC), who presented to our neurology department over the last 30 yearsWe detected 38 cases of apparent ASC; Our analysis revealed a wide array of different sporadic conditions and 5 cases of genetic choreaThe differential diagnosis of ASC is extensive and challenging.
舞蹈症有多种原因，包括神经退行性、药物性、结构性、代谢性、感染性、免疫性和副肿瘤性过程。我们回顾了 1991 年至 2022 年期间在我们神经内科（Hospital Fundación Jimenez Diaz）就诊的、有明显散发性舞蹈运动且无相关家族史的患者的临床记录。我们共发现 38 例明显散发性舞蹈症（ASC）；分析显示 5 例为遗传性舞蹈症（包括 3 例亨廷顿病），6 例为自身免疫/血液系统疾病；6 例与药物相关，5 例为代谢-血管性，5 例为其他原因，4 例为混合病因。8 例病因不明确。ASC 的鉴别诊断广泛且具有挑战性。
舞蹈症有多种遗传性和散发性病因。我们回顾了过去 30 年来在我们神经内科就诊的、有明显散发性舞蹈症（ASC）的患者的临床记录。我们共发现 38 例明显 ASC；分析显示，有多种不同的散发性疾病，以及 5 例遗传性舞蹈症。ASC 的鉴别诊断广泛且具有挑战性。
