Aghahosseini Farzaneh, HafeziMotlagh Kimia, Derakhshan Samira, Bahrami Hosna
Department of Oral Medicine Faculty of Dentistry Tehran University of Medical Sciences Tehran Iran.
Dental Research Center Dentistry Research Institute Tehran University of Medical Sciences Tehran Iran.
Clin Case Rep. 2023 Sep 8;11(9):e7898. doi: 10.1002/ccr3.7898. eCollection 2023 Sep.
Secondary neoplasms were reported as one of the complicated complications of childhood cancer treatment. Salivary gland carcinoma is rare, and mucoepidermoid carcinoma (MEC) is the most prevalent subtype. Secondary neoplasms following neuroblastoma are not often described due to poor long-term survival. The exact cause of these tumors in children, and adults is not clearly known, but they are often observed after head, and neck radiotherapy and mainly involve main salivary glands, especially the parotid. Hence, we report a case of MEC with telangiectasia in the salivary glands of a 20-year-old girl with complaint of a palatal swelling who was treated with chemotherapy (etoposide, G-CSF, cyclophosphamide) without radiotherapy since childhood (18 months) in terms of neuroblastoma. Based on our knowledge, only three cases of MEC following neuroblastoma have been reported before, all of which involved the major salivary glands. Survivors of primary neoplasms who were treated are at risk of secondary malignant neoplasms, which usually occur at a long interval from the primary neoplasm (5-15 years), which necessitates long and close follow-up.
继发性肿瘤被报道为儿童癌症治疗的复杂并发症之一。涎腺癌罕见，黏液表皮样癌（MEC）是最常见的亚型。由于神经母细胞瘤患者长期生存率低，因此关于神经母细胞瘤后继发性肿瘤的报道并不常见。儿童和成人这些肿瘤的确切病因尚不清楚，但常在头颈部放疗后出现，主要累及主要涎腺，尤其是腮腺。因此，我们报告一例20岁女孩，自幼（18个月）因神经母细胞瘤接受化疗（依托泊苷、粒细胞集落刺激因子、环磷酰胺）而非放疗，现主诉腭部肿胀，其涎腺出现伴有毛细血管扩张的黏液表皮样癌。据我们所知，此前仅报道过3例神经母细胞瘤后继发黏液表皮样癌的病例，均累及主要涎腺。接受原发性肿瘤治疗的幸存者有发生继发性恶性肿瘤的风险，继发性恶性肿瘤通常在原发性肿瘤发生很长一段时间后（5 - 15年）出现，这就需要长期密切随访。
