Chen Min, Zhu Jieying, Luo Hongyang, Mu Wangjing, Guo Liang
School of Exercise and Health and Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport, Shanghai 200438, China.
Genes Dis. 2023 Apr 25;11(2):687-700. doi: 10.1016/j.gendis.2023.03.021. eCollection 2024 Mar.
Neuregulin 4 (Nrg4), an epidermal growth factor (EGF) family member, can bind to and activate the ErbB4 receptor tyrosine kinase. Nrg4 has five different isoforms by alternative splicing and performs a wide variety of functions. Nrg4 is involved in a spectrum of physiological processes including neurobiogenesis, lipid metabolism, glucose metabolism, thermogenesis, and angiogenesis. In pathological processes, Nrg4 inhibits inflammatory factor levels and suppresses apoptosis in inflammatory diseases. In addition, Nrg4 could ameliorate obesity, insulin resistance, and cardiovascular diseases. Furthermore, Nrg4 improves non-alcoholic fatty liver disease (NAFLD) by promoting autophagy, improving lipid metabolism, and inhibiting cell death of hepatocytes. Besides, Nrg4 is closely related to the development of cancer, hyperthyroidism, and some other diseases. Therefore, elucidation of the functional role and mechanisms of Nrg4 will provide a clearer view of the therapeutic potential and possible risks of Nrg4.
神经调节蛋白4（Nrg4）是表皮生长因子（EGF）家族成员，可结合并激活ErbB4受体酪氨酸激酶。Nrg4通过可变剪接产生五种不同的异构体，并发挥多种功能。Nrg4参与一系列生理过程，包括神经发生、脂质代谢、葡萄糖代谢、产热和血管生成。在病理过程中，Nrg4可抑制炎症因子水平并抑制炎症性疾病中的细胞凋亡。此外，Nrg4可改善肥胖、胰岛素抵抗和心血管疾病。此外，Nrg4通过促进自噬、改善脂质代谢和抑制肝细胞死亡来改善非酒精性脂肪性肝病（NAFLD）。此外，Nrg4与癌症、甲状腺功能亢进和其他一些疾病的发生密切相关。因此，阐明Nrg4的功能作用和机制将更清楚地了解Nrg4的治疗潜力和可能的风险。
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