Zhu Jie-Ying, Chen Min, Mu Wang-Jing, Luo Hong-Yang, Guo Liang
School of Kinesiology, Shanghai University of Sport, Shanghai 200438, China.
Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport, Shanghai 200438, China.
Genes Dis. 2022 Apr 22;10(5):1833-1845. doi: 10.1016/j.gendis.2022.03.018. eCollection 2023 Sep.
is a conserved gene in evolution which is widely expressed in many tissues in mammals. Accumulating evidence has revealed multiple functions of Higd1a, as a mitochondrial inner membrane protein, in the regulation of metabolic homeostasis. It plays an important role in anti-apoptosis and promotes cellular survival in several cell types under hypoxic condition. And the survival of porcine Sertoli cells facilitated by Higd1a helps to support reproduction. In some cases, Higd1a can serve as a sign of metabolic stress. Over the past several years, a considerable amount of studies about how tumor fate is determined and how cancerous proliferation is regulated by Higd1a have been performed. In this review, we summarize the physiological functions of Higd1a in metabolic homeostasis and its pathophysiological roles in distinct diseases including cancer, nonalcoholic fatty liver disease (NAFLD), type II diabetes and mitochondrial diseases. The prospect of Higd1a with potential to preserve mammal health is also discussed. This review might pave the way for Higd1a-based research and application in clinical practice.
是一种在进化中保守的基因，在哺乳动物的许多组织中广泛表达。越来越多的证据表明，作为一种线粒体内膜蛋白，Higd1a在调节代谢稳态方面具有多种功能。它在抗凋亡中起重要作用，并在缺氧条件下促进多种细胞类型的细胞存活。Higd1a促进猪支持细胞的存活有助于维持生殖。在某些情况下，Higd1a可作为代谢应激的标志。在过去几年中，已经进行了大量关于Higd1a如何决定肿瘤命运以及如何调节癌细胞增殖的研究。在这篇综述中，我们总结了Higd1a在代谢稳态中的生理功能及其在包括癌症、非酒精性脂肪性肝病（NAFLD）、II型糖尿病和线粒体疾病在内的不同疾病中的病理生理作用。还讨论了Higd1a在维护哺乳动物健康方面的潜力前景。这篇综述可能为基于Higd1a的研究及其在临床实践中的应用铺平道路。
Zotero 插件
