Huang Yonggao, Tang Xiaolu, Wang Chengwei, Hu Qiuhong, Wang Bian, Yang Xiuzhen, Sun Xiaojun, Shen Meilong
Department of Thoracic Surgery, Taizhou Hospital of Traditional Chinese Medicine Taizhou 225300, Jiangsu, China.
Department of Hepatology, Taizhou Hospital of Traditional Chinese Medicine Taizhou 225300, Jiangsu, China.
Am J Transl Res. 2023 Aug 15;15(8):5331-5338. eCollection 2023.
To clarify the association of serum alpha-fetoprotein (AFP) with inflammatory markers interleukin (IL)-6 and tumor necrosis factor (TNF)-α in patients with chronic hepatitis B (CHB) during the immune-clearance phase in Eastern China.
This research selected 60 CHB patients during the immune clearance phase who tested positive for AFP, including 32 cases treated by non-antiviral therapy (experimental group) and 28 cases treated by antiviral therapy (positive control group). Another 30 cases tested negative for AFP were set as a negative control group. The correlations of serum AFP with IL-6 and TNF-α in patients were analyzed.
HBV DNA clearance in patients receiving antiviral therapy, in both the positive or negative control groups, was not significantly related to other clinical data. In the experimental group, a positive correlation of HBV DNA clearance with serum AFP level (r=0.5126, P=0.0027), alanine aminotransferase (r=0.3924, P=0.0263), and total bilirubin (r=0.5126, P=0.0027) was found. The experimental and positive control groups exhibited elevated serum IL-6 and TNF-α contents versus the negative control group (P<0.05). A positive association of AFP with IL-6 and TNF-α was also identified.
Serum AFP level is positively related to IL-6 and TNF-α levels in CHB patients during the immune-clearance phase.
阐明中国东部慢性乙型肝炎（CHB）患者免疫清除期血清甲胎蛋白（AFP）与炎症标志物白细胞介素（IL）-6和肿瘤坏死因子（TNF）-α之间的关联。
本研究选取60例免疫清除期AFP检测呈阳性的CHB患者，其中32例接受非抗病毒治疗（实验组），28例接受抗病毒治疗（阳性对照组）。另外30例AFP检测呈阴性的患者设为阴性对照组。分析患者血清AFP与IL-6和TNF-α的相关性。
在阳性或阴性对照组中，接受抗病毒治疗患者的乙肝病毒脱氧核糖核酸（HBV DNA）清除情况与其他临床数据无显著相关性。在实验组中，发现HBV DNA清除与血清AFP水平（r = 0.5126，P = 0.0027）、谷丙转氨酶（r = 0.3924，P = 0.0263）和总胆红素（r = 0.5126，P = 0.0027）呈正相关。与阴性对照组相比，实验组和阳性对照组血清IL-6和TNF-α含量升高（P < 0.05）。还发现AFP与IL-6和TNF-α呈正相关。
免疫清除期CHB患者血清AFP水平与IL-6和TNF-α水平呈正相关。
