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减肥手术后肠道微生物群会使体温升高。

Gut microbiota turn up the heat after bariatric surgery.

作者信息

Hankir Mohammed K

机构信息

Department of General, Visceral, Transplantation, Vascular and Pediatric Surgery, University Hospital Wuerzburg, Wuerzburg, Germany.

出版信息

Cell Stress. 2023 Aug 15;7(10):90-94. doi: 10.15698/cst2023.10.290. eCollection 2023 Oct 9.

DOI:10.15698/cst2023.10.290
PMID:37693093
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10485695/
Abstract

Bariatric surgeries like vertical sleeve gastrectomy (VSG) and Roux-en-Y gastric bypass (RYGB) cause well-established shifts in the gut microbiota, but how this contributes to their unique metabolic benefits is poorly understood. Jin and Yadav now provide two complementary lines of evidence suggesting that gut microbiota-derived metabolites after VSG and RYGB activate thermogenesis in fat through distinct mechanisms, to in turn promote weight loss and/or improvements in glycemic control.

摘要

像垂直袖状胃切除术（VSG）和Roux-en-Y胃旁路术（RYGB）这样的减肥手术会导致肠道微生物群发生公认的变化，但人们对其如何产生独特的代谢益处却知之甚少。Jin和Yadav现在提供了两条互补的证据，表明VSG和RYGB术后肠道微生物群衍生的代谢产物通过不同机制激活脂肪中的产热作用，进而促进体重减轻和/或改善血糖控制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc43/10485695/269fc6ee3640/ces-07-090-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc43/10485695/269fc6ee3640/ces-07-090-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc43/10485695/269fc6ee3640/ces-07-090-g001.jpg

相似文献

1
Gut microbiota turn up the heat after bariatric surgery.减肥手术后肠道微生物群会使体温升高。
Cell Stress. 2023 Aug 15;7(10):90-94. doi: 10.15698/cst2023.10.290. eCollection 2023 Oct 9.
2
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3
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4
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本文引用的文献

1
Mechanisms of bariatric surgery for weight loss and diabetes remission.减重手术治疗肥胖和糖尿病缓解的机制。
J Diabetes. 2023 Sep;15(9):736-752. doi: 10.1111/1753-0407.13443. Epub 2023 Jul 13.
2
Vertical sleeve gastrectomy-derived gut metabolite licoricidin activates beige fat thermogenesis to combat obesity.胃袖状切除术衍生肠道代谢产物甘草亭酸激活米色脂肪产热以对抗肥胖。
Theranostics. 2023 May 21;13(9):3103-3116. doi: 10.7150/thno.81893. eCollection 2023.
3
Metabolic bariatric surgery as a therapeutic option for patients with type 2 diabetes: A meta-analysis and network meta-analysis of randomized controlled trials.
代谢减重手术作为 2 型糖尿病患者的治疗选择：一项随机对照试验的荟萃分析和网络荟萃分析。
Diabetes Obes Metab. 2023 Aug;25(8):2362-2373. doi: 10.1111/dom.15117. Epub 2023 Jun 5.
4
Gut microbiome modified by bariatric surgery improves insulin sensitivity and correlates with increased brown fat activity and energy expenditure.减重手术改变肠道微生物群，改善胰岛素敏感性，并与棕色脂肪活性和能量消耗增加相关。
Cell Rep Med. 2023 May 16;4(5):101051. doi: 10.1016/j.xcrm.2023.101051.
5
Mechanisms underlying the efficacy of a rodent model of vertical sleeve gastrectomy - A focus on energy expenditure.垂直袖状胃切除术啮齿动物模型疗效的作用机制 - 重点关注能量消耗。
Mol Metab. 2023 Jul;73:101739. doi: 10.1016/j.molmet.2023.101739. Epub 2023 May 13.
6
Branched-Chain Amino Acids and Insulin Resistance, from Protein Supply to Diet-Induced Obesity.支链氨基酸与胰岛素抵抗：从蛋白质供给到饮食诱导的肥胖。
Nutrients. 2022 Dec 23;15(1):68. doi: 10.3390/nu15010068.
7
Gut Microbiota Profile in Adults Undergoing Bariatric Surgery: A Systematic Review.成人减肥手术前后肠道微生物群特征：系统评价。
Nutrients. 2022 Nov 23;14(23):4979. doi: 10.3390/nu14234979.
8
Effects of a Phosphodiesterase inhibitor on the Browning of Adipose Tissue in Mice.磷酸二酯酶抑制剂对小鼠脂肪组织褐变的影响。
Biomedicines. 2022 Aug 1;10(8):1852. doi: 10.3390/biomedicines10081852.
9
Brown Adipose Tissue-A Translational Perspective.棕色脂肪组织——转化视角。
Endocr Rev. 2023 Mar 4;44(2):143-192. doi: 10.1210/endrev/bnac015.
10
Anti-obesity drug discovery: advances and challenges.抗肥胖药物的发现：进展与挑战。
Nat Rev Drug Discov. 2022 Mar;21(3):201-223. doi: 10.1038/s41573-021-00337-8. Epub 2021 Nov 23.