细胞内氯离子通道1与肿瘤
Intracellular chloride channel 1 and tumor.
作者信息
Zhang Li, Chen Xingyue, Yao Shun, Zheng Liming, Yang Xingyue, Wang Yongfeng, Li Xin, Wu Enqin, Tuo Biguang
机构信息
Department of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University Zunyi, Guizhou, China.
The Collaborative Innovation Center of Tissue Damage Repair and Regenerative Medicine of Zunyi Medical University Zunyi, Guizhou, China.
出版信息
Am J Cancer Res. 2023 Aug 15;13(8):3300-3314. eCollection 2023.
As the major intracellular anion, chloride plays an important role in maintaining intracellular and extracellular ion homeostasis, osmotic pressure, and cell volume. Intracellular chloride channel 1, which has the physiological role of forming membrane proteins in the lipid bilayer and playing ion channels, is a hot research topic in recent years. It has been found that CLIC1 does not only act as an ion channel but also participates in cell cycle regulation, apoptosis, and intracellular oxidation; thus, it participates in the proliferation, invasion, and migration of various tumor cells in various systems throughout the body. At the same time, CLIC1 is highly expressed in tumor cells and is associated with malignancy and a poor prognosis. This paper reviews the pathological mechanisms of CLIC1 in systemic diseases, which is important for the early diagnosis, treatment, and prognosis of systemic diseases associated with CLIC1 expression.
作为主要的细胞内阴离子，氯离子在维持细胞内外离子稳态、渗透压和细胞体积方面发挥着重要作用。细胞内氯离子通道1在脂质双分子层中形成膜蛋白并发挥离子通道的生理作用，是近年来的一个热门研究课题。研究发现，CLIC1不仅作为离子通道发挥作用，还参与细胞周期调控、细胞凋亡和细胞内氧化；因此，它参与全身各个系统中各种肿瘤细胞的增殖、侵袭和迁移。同时，CLIC1在肿瘤细胞中高表达，与恶性肿瘤和不良预后相关。本文综述了CLIC1在全身性疾病中的病理机制，这对于与CLIC1表达相关的全身性疾病的早期诊断、治疗和预后具有重要意义。
Zotero 插件