物理治疗在经证实的人乳头瘤病毒相关口腔黏膜下纤维化病例中的作用
Role of Physiotherapy in HPV Proven Cases of Oral Submucous Fibrosis.
作者信息
Syed Farkhanda, Wani Hafiz Ul Islam, Jha Satyendra K, Banerjee Kalyan, Singh Sudhanshu, Kumar Anjali P
机构信息
Department of Microbiology, Dasmesh Institute of Research and Dental Sciences, Faridkot, Punjab, India.
Department of Physiotherapy, Elaj Medical Centre LLC, Ajman, UAE.
出版信息
J Pharm Bioallied Sci. 2023 Jul;15(Suppl 2):S837-S839. doi: 10.4103/jpbs.jpbs_273_23. Epub 2023 Jul 11.
BACKGROUND
To assess the role of physiotherapy in human papillomavirus (HPV) proven cases of oral submucous fibrosis (OSMF).
MATERIALS AND METHODS
Overall, 100 patients got recruited. Only histopathologic confirmed cases of OSMF were enrolled. Purified DNA of tissue blocks was quantified by spectrophotometry. Prevalence of HPV was evaluated. The participants got randomized into 2 cohorts: HPV positive cases and HPV negative cases. Physiotherapy was done and outcome was done and outcome was assessed and compared. Assessment of results was done by SPSS software followed by statistical evaluation.
RESULTS
HPV was seen in 80% of the patients. Mean mouth opening pretreatment and postphysiotherapy among patients with HPV positive status was 26.31 mm and 30.12 mm, respectively. Mean mouth opening pretreatment and postphysiotherapy among patients with HPV negative status was 25.11 mm and 29.74 mm, respectively. Nonsignificant results were obtained while comparing the outcome of physiotherapy among HPV positive and negative groups.
CONCLUSION
Outcome of physiotherapy among OSMF patients is independent of HPV status.
背景
评估物理治疗在经人乳头瘤病毒（HPV）证实的口腔黏膜下纤维化（OSMF）病例中的作用。
材料与方法
共招募了100名患者。仅纳入经组织病理学确诊的OSMF病例。通过分光光度法对组织块的纯化DNA进行定量。评估HPV的患病率。将参与者随机分为2组：HPV阳性病例组和HPV阴性病例组。进行物理治疗并评估结果并进行比较。通过SPSS软件进行结果评估，随后进行统计学评价。
结果
80%的患者检测出HPV。HPV阳性患者治疗前和物理治疗后的平均开口度分别为26.31毫米和30.12毫米。HPV阴性患者治疗前和物理治疗后的平均开口度分别为25.11毫米和29.74毫米。比较HPV阳性和阴性组的物理治疗结果时，未获得显著结果。
结论
OSMF患者物理治疗的结果与HPV状态无关。
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