School of Medicine, University of Utah, Salt Lake City, Utah 84043, USA.
School of Medicine, University of Nevada, Reno, NV 89036, USA.
Curr Alzheimer Res. 2023;20(6):394-402. doi: 10.2174/1567205020666230911125646.
Neurodegenerative diseases (NDDs) encapsulate conditions in which neural cell populations are perpetually degraded and nervous system function destroyed. Generally linked to increased age, the proportion of patients diagnosed with a NDD is growing as human life expectancies rise. Traditional NDD therapies and surgical interventions have been limited. However, recent breakthroughs in understanding disease pathophysiology, improved drug delivery systems, and targeted pharmacologic agents have allowed innovative treatment approaches to treat NDDs. A common denominator for administering these new treatment options is the requirement for neurosurgical skills. In the present narrative review, we highlight exciting and novel preclinical and clinical discoveries being integrated into NDD care. We also discuss the traditional role of neurosurgery in managing these neurodegenerative conditions and emphasize the critical role of neurosurgery in effectuating these newly developed treatments.
神经退行性疾病（NDD）包括神经细胞群体持续退化和神经系统功能破坏的情况。通常与年龄增长有关，随着人类预期寿命的延长，被诊断患有 NDD 的患者比例正在增加。传统的 NDD 治疗方法和手术干预措施受到限制。然而，近年来对疾病病理生理学的理解、改进的药物输送系统和靶向药物的突破，使得治疗 NDD 的创新治疗方法成为可能。这些新治疗方案的一个共同点是需要神经外科技能。在本叙述性综述中，我们强调了正在整合到 NDD 护理中的令人兴奋和新颖的临床前和临床发现。我们还讨论了神经外科在治疗这些神经退行性疾病中的传统作用，并强调了神经外科在实施这些新开发的治疗方法中的关键作用。
