Immunology Unit, Department of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Aliment Pharmacol Ther. 2023 Nov;58(10):1062-1074. doi: 10.1111/apt.17714. Epub 2023 Sep 11.
Non-alcoholic fatty liver disease (NAFLD) represents a significant health threat worldwide. The growing trend towards an aging population, along with an alarming rise in obesity and diabetes, may have significant implications for the burden of NAFLD.
To assess the impact of NAFLD on the elderly.
We utilised data from the Global Burden of Disease study between 2010 and 2019 to conduct a comprehensive analysis of the prevalence, mortality, and disability-adjusted life years (DALYs) associated with NAFLD in the elderly (65-89 years), stratified by region, nation, sociodemographic Index and sex.
Globally, there were an estimated 228 million cases, 87,230 deaths and 1.46 million DALYs attributed to NAFLD in the elderly. Geographically, the Western Pacific region had the highest burden of NAFLD in the elderly. From 2010 to 2019, there was an increasing prevalence rate in all areas, with the most pronounced change observed in the Western Pacific region (annual percentage change (APC) +0.95%, p < 0.001). Over the study period, there was a more rapid increase in NAFLD prevalence in men (APC +0.74%, p < 0.001) than in women (APC +0.63%, p < 0.001). In most regions, death and DALYs rates have declined, with the exception of the Americas, where there was a slight increase (APC +0.25%, p = 0.002 and 0.38%, p < 0.001, respectively).
Over the past decade, the burden of NAFLD in the elderly has been increasing, necessitating immediate and inclusive measures to tackle the rising burden.
非酒精性脂肪性肝病（NAFLD）是全球范围内的一个重大健康威胁。人口老龄化趋势的增长，加上肥胖症和糖尿病发病率的惊人上升，可能对 NAFLD 的负担产生重大影响。
评估 NAFLD 对老年人的影响。
我们利用 2010 年至 2019 年全球疾病负担研究的数据，对老年人（65-89 岁）中与 NAFLD 相关的患病率、死亡率和残疾调整生命年（DALY）进行了全面分析，按地区、国家、社会人口指数和性别进行了分层。
全球范围内，估计有 2.28 亿例、87230 例死亡和 146 万 DALY 归因于老年人的 NAFLD。从地理上看，西太平洋地区老年人的 NAFLD 负担最重。从 2010 年到 2019 年，所有地区的患病率都呈上升趋势，西太平洋地区的变化最为显著（年变化百分比（APC）+0.95%，p<0.001）。在研究期间，男性（APC+0.74%，p<0.001）的 NAFLD 患病率增长速度快于女性（APC+0.63%，p<0.001）。在大多数地区，死亡率和 DALY 率都有所下降，但美洲地区略有上升（APC+0.25%，p=0.002 和 0.38%，p<0.001）。
在过去十年中，老年人的 NAFLD 负担一直在增加，需要立即采取全面措施来应对这一日益增加的负担。
