Department of Pediatric Allergy and Clinical Immunology, Basaksehir Cam and Sakura City Hospital, Istanbul, Turkey;
Department of Pediatric Allergy and Clinical Immunology, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey.
Allergol Immunopathol (Madr). 2023 Sep 1;51(5):66-71. doi: 10.15586/aei.v51i5.921. eCollection 2023.
Atopic dermatitis (AD) is a chronic inflammatory skin disease that can occur at any age. This study aimed to evaluate the impact of food allergy on disease severity as well as clinical/laboratory findings in children with AD.
Clinical and laboratory data of AD patients evaluated for food allergy between January 2021 and December 2022 were examined retrospectively.
Of the 52 patients evaluated, 32 (61.5%) were males, with a median age of 6 months (2-118 months). Among them, 26 (50%) had food allergies (FA) and five (9.6%) had inhalant allergen sensitivity. No significant difference in AD severity was observed between patients with and without FA. However, the FA group showed higher serum lactate dehydrogenase (LDH) levels (343.3 ± 81.5 U/L vs 297.7 ± 77.4 U/L; = 0.011) and lower red cell distribution width (RDW). Inhalant allergen sensitivity was associated with higher AD severity.
While guidelines recommend investigating food allergies in moderate to severe AD, this study found no significant difference in the relationship between AD severity and the presence of FA. However, inhalant allergen sensitivity was linked to increased AD severity. Therefore, a comprehensive patient history should include an evaluation of food allergies in children with AD, regardless of disease severity. Elimination and provocation tests related to suspected food items should be performed, and allergenic foods should be removed from the diet if they are found to contribute to the allergy.
特应性皮炎（AD）是一种可发生于任何年龄的慢性炎症性皮肤病。本研究旨在评估食物过敏对 AD 患儿疾病严重程度及临床/实验室发现的影响。
回顾性分析了 2021 年 1 月至 2022 年 12 月间评估食物过敏的 AD 患者的临床和实验室数据。
在 52 例评估的患者中，32 例（61.5%）为男性，中位年龄为 6 个月（2-118 个月）。其中，26 例（50%）有食物过敏（FA），5 例（9.6%）有吸入性过敏原敏感。FA 组与无 FA 组 AD 严重程度无显著差异。然而，FA 组的血清乳酸脱氢酶（LDH）水平较高（343.3 ± 81.5 U/L vs 297.7 ± 77.4 U/L； = 0.011），红细胞分布宽度（RDW）较低。吸入性过敏原敏感与 AD 严重程度增加相关。
尽管指南建议在中重度 AD 中调查食物过敏，但本研究发现 AD 严重程度与 FA 之间无显著关系。然而，吸入性过敏原敏感与 AD 严重程度增加有关。因此，全面的患者病史应包括评估 AD 患儿的食物过敏情况，无论疾病严重程度如何。如果怀疑食物过敏，应进行相关的食物消除和激发试验，并从饮食中去除致敏食物。
