Clinical Medical Research Center, The Second Affiliated Hospital of Guangxi Medical University, Nanning, 530007, Guangxi, China.
Guangxi International Travel Healthcare Centre (Port Clinic of Nanning Customs District), Nanning, 530021, Guangxi, China.
Cell Biochem Biophys. 2023 Dec;81(4):659-671. doi: 10.1007/s12013-023-01173-w. Epub 2023 Sep 11.
Liver fibrosis is a dynamic pathological process in which the structure and function of the liver abnormally change due to long-term complex inflammatory reactions and chronic liver injury caused by multiple internal and external factors. Previous studies believed that the activation of hepatic stellate cells is a critical part of the occurrence and development of liver fibrosis. However, an increasing number of studies have indicated that the macrophage plays an important role as a central regulator in liver fibrosis, and it directly affects the development and recovery of liver fibrosis. Studies of macrophages and liver fibrosis in the recent 10 years will be reviewed in this paper. This review will not only clarify the molecular mechanism of liver fibrosis regulated by macrophages but also provide new strategies and methods for ameliorating and treating liver fibrosis.
肝纤维化是一种动态的病理过程，由于多种内外因素引起的长期复杂炎症反应和慢性肝损伤，肝脏的结构和功能异常改变。先前的研究认为，肝星状细胞的激活是肝纤维化发生和发展的关键部分。然而，越来越多的研究表明，巨噬细胞作为肝纤维化中央调控器发挥着重要作用，它直接影响肝纤维化的发展和恢复。本文对近 10 年来巨噬细胞与肝纤维化的研究进行综述。该综述不仅阐明了巨噬细胞调节肝纤维化的分子机制，而且为改善和治疗肝纤维化提供了新的策略和方法。
