Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, China; School of Medicine and Dentistry, Griffith University, Gold Coast, Queensland, Australia.
Suzhou Hospital of Anhui Medical University, China; Suzhou Municipal Hospital of Anhui Province, China.
Ecotoxicol Environ Saf. 2023 Oct 1;264:115452. doi: 10.1016/j.ecoenv.2023.115452. Epub 2023 Sep 9.
Epidemiological studies show that outdoor artificial light at night (ALAN) is linked to metabolic hazards, but its association with metabolic syndrome (MetS) remains unclear. We aimed to investigate the association of outdoor ALAN with MetS in middle-aged and elderly Chinese.
From 2017-2020, we conducted a cross-sectional study in a total of 109,452 participants living in ten cities of eastern China. MetS was defined by fasting blood glucose (FG), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), blood pressure (BP), and waist circumference (WC). In 2021, we followed up 4395 participants without MetS at the baseline. Each participant's five-year average exposure to outdoor ALAN, as well as their exposure to green space type, were measured through matching to their address. Generalized linear models were used to assess the associations of outdoor ALAN with MetS. Stratified analyses were performed by sex, age, region, physical activity, and exposure to green space.
In the cross-sectional study, compared to the first quantile (Q1) of outdoor ALAN exposure, the odds ratios (ORs) of MetS were 1.156 [95 % confidence interval (CI): 1.111-1.203] and 1.073 (95 %CI: 1.021-1.128) respectively in the third and fourth quantiles (Q3, Q4) of outdoor ALAN exposure. The follow-up study found that, compared to the first quantile (Q1) of outdoor ALAN exposure, the OR of MetS in Q4 of ALAN exposure was 1.204 (95 %CI: 1.019-1.422). Adverse associations of ALAN with MetS components, including high FG, high TG, and obesity, were also found. Greater associations of ALAN with MetS were found in males, the elderly, urban residents, those with low frequency of physical activity, and those living in areas with low levels of grass cover and tree cover.
Outdoor ALAN exposure is associated with an increased MetS risk, especially in males, the elderly, urban residents, those lacking physical activity, and those living in lower levels of grass cover and tree cover.
流行病学研究表明，夜间室外人工光（ALAN）与代谢危害有关，但它与代谢综合征（MetS）的关系尚不清楚。我们旨在研究中年和老年人中室外 ALAN 与 MetS 的关系。
2017-2020 年，我们在中国东部十个城市进行了一项共 109452 名参与者的横断面研究。MetS 通过空腹血糖（FG）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、血压（BP）和腰围（WC）来定义。2021 年，我们对基线时无 MetS 的 4395 名参与者进行了随访。通过与参与者的地址相匹配，测量了每位参与者五年的室外 ALAN 平均暴露量以及他们接触的绿地类型。使用广义线性模型评估室外 ALAN 与 MetS 的关系。通过性别、年龄、地区、体力活动和暴露于绿地进行分层分析。
在横断面研究中，与室外 ALAN 暴露的第一分位数（Q1）相比，第三分位数（Q3）和第四分位数（Q4）的 MetS 比值比（ORs）分别为 1.156 [95%置信区间（CI）：1.111-1.203]和 1.073（95%CI：1.021-1.128）。随访研究发现，与室外 ALAN 暴露的第一分位数（Q1）相比，Q4 的 MetS 比值比（OR）为 1.204（95%CI：1.019-1.422）。ALAN 与 MetS 成分（包括高 FG、高 TG 和肥胖）的不良关联也被发现。ALAN 与 MetS 的关联在男性、老年人、城市居民、体力活动频率较低的人群以及居住在草地和树木覆盖率较低地区的人群中更为显著。
室外 ALAN 暴露与 MetS 风险增加有关，尤其是在男性、老年人、城市居民、缺乏体力活动的人群以及居住在草地和树木覆盖率较低地区的人群中。
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