夜间户外人工光源暴露与妊娠期糖尿病：一项病例对照研究。
Outdoor artificial light at night exposure and gestational diabetes mellitus: a case-control study.
作者信息
Sun Qi, Ye Fang, Liu Jing, Yang Yang, Hui Qin, Chen Yuanmei, Liu Die, Guo Jianning, Wang Chao, Lv Di, Tang Lijuan, Zhang Qi
机构信息
National Center for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, Department of Pediatrics, China-Japan Friendship Hospital, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing, China.
Precision and Smart Imaging Laboratory, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
出版信息
Front Public Health. 2024 Apr 10;12:1396198. doi: 10.3389/fpubh.2024.1396198. eCollection 2024.
OBJECTIVE
This study aims to explore the association between outdoor artificial light at night (ALAN) exposure and gestational diabetes mellitus (GDM).
METHODS
This study is a retrospective case-control study. According with quantiles, ALAN has been classified into three categories (Q1-Q3). GDM was diagnosed through oral glucose tolerance tests. Conditional logistic regression models were used to evaluate the association between ALAN exposure and GDM risk. The odds ratio (OR) with 95% confidence interval (CI) was used to assess the association. Restricted cubic spline analysis (RCS) was utilized to investigate the no liner association between ALAN and GDM.
RESULTS
A total of 5,720 participants were included, comprising 1,430 individuals with GDM and 4,290 matched controls. Pregnant women exposed to higher levels of ALAN during the first trimester exhibited an elevated risk of GDM compared to those with lower exposure levels (Q2 OR = 1.39, 95% CI 1.20-1.63, < 0.001); (Q3 OR = 1.70, 95% CI 1.44-2.00, < 0.001). Similarly, elevated ALAN exposure during the second trimester also conferred an increased risk of GDM (second trimester: Q2 OR = 1.70, 95% CI 1.45-1.98, < 0.001; Q3 OR = 2.08, 95% CI 1.77-2.44, < 0.001). RCS showed a nonlinear association between ALAN exposure and GDM risk in second trimester pregnancy, with a threshold value of 4.235.
CONCLUSION
Outdoor ALAN exposure during pregnancy is associated with an increased risk of GDM.
目的
本研究旨在探讨夜间户外人工光暴露（ALAN）与妊娠期糖尿病（GDM）之间的关联。
方法
本研究为回顾性病例对照研究。根据分位数，ALAN被分为三类（Q1-Q3）。通过口服葡萄糖耐量试验诊断GDM。使用条件逻辑回归模型评估ALAN暴露与GDM风险之间的关联。采用比值比（OR）及95%置信区间（CI）评估该关联。利用限制立方样条分析（RCS）研究ALAN与GDM之间的非线性关联。
结果
共纳入5720名参与者，其中1430例为GDM患者，4290例为匹配的对照组。与暴露水平较低的孕妇相比，孕早期暴露于较高水平ALAN的孕妇患GDM的风险升高（Q2组OR = 1.39，95% CI 1.20-1.63，P < 0.001）；（Q3组OR = 1.70，95% CI 1.44-2.00，P < 0.001）。同样，孕中期ALAN暴露水平升高也会增加患GDM的风险（孕中期：Q2组OR = 1.70，95% CI 1.45-1.98，P < 0.001；Q3组OR = 2.08，95% CI 1.77-2.44，P < 0.001）。RCS显示孕中期ALAN暴露与GDM风险之间存在非线性关联，阈值为4.235。
结论
孕期户外ALAN暴露与GDM风险增加有关。
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